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Designing materials to direct stem-cell fate

Author

Listed:
  • Matthias P. Lutolf

    (Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne)

  • Penney M. Gilbert

    (Baxter Laboratory in Stem Cell Biology, Institute for Stem Cells and Regenerative Medicine, Stanford University School of Medicine)

  • Helen M. Blau

    (Baxter Laboratory in Stem Cell Biology, Institute for Stem Cells and Regenerative Medicine, Stanford University School of Medicine)

Abstract

Proper tissue function and regeneration rely on robust spatial and temporal control of biophysical and biochemical microenvironmental cues through mechanisms that remain poorly understood. Biomaterials are rapidly being developed to display and deliver stem-cell-regulatory signals in a precise and near-physiological fashion, and serve as powerful artificial microenvironments in which to study and instruct stem-cell fate both in culture and in vivo. Further synergism of cell biological and biomaterials technologies promises to have a profound impact on stem-cell biology and provide insights that will advance stem-cell-based clinical approaches to tissue regeneration.

Suggested Citation

  • Matthias P. Lutolf & Penney M. Gilbert & Helen M. Blau, 2009. "Designing materials to direct stem-cell fate," Nature, Nature, vol. 462(7272), pages 433-441, November.
    • Handle: RePEc:nat:nature:v:462:y:2009:i:7272:d:10.1038_nature08602
    DOI: 10.1038/nature08602
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    Cited by:

    1. Yuanxiong Cao & Jiayi Tan & Haoran Zhao & Ting Deng & Yunxia Hu & Junhong Zeng & Jiawei Li & Yifan Cheng & Jiyuan Tang & Zhiwei Hu & Keer Hu & Bing Xu & Zitian Wang & Yaojiong Wu & Peter E. Lobie & Sh, 2022. "Bead-jet printing enabled sparse mesenchymal stem cell patterning augments skeletal muscle and hair follicle regeneration," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    2. Céline Labouesse & Bao Xiu Tan & Chibeza C. Agley & Moritz Hofer & Alexander K. Winkel & Giuliano G. Stirparo & Hannah T. Stuart & Christophe M. Verstreken & Carla Mulas & William Mansfield & Paul Ber, 2021. "StemBond hydrogels control the mechanical microenvironment for pluripotent stem cells," Nature Communications, Nature, vol. 12(1), pages 1-17, December.

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