IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v462y2009i7272d10.1038_nature08511.html
   My bibliography  Save this article

CD8+ T lymphocyte mobilization to virus-infected tissue requires CD4+ T-cell help

Author

Listed:
  • Yusuke Nakanishi

    (Yale University School of Medicine, New Haven, Connecticut 06520, USA)

  • Bao Lu

    (Children’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Craig Gerard

    (Children’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Akiko Iwasaki

    (Yale University School of Medicine, New Haven, Connecticut 06520, USA)

Abstract

A new way to help Successful defence against intracellular pathogens requires neutralizing antibodies and cytotoxic CD8+ T lymphocyte (CTL) responses, both largely dependent on the activity of CD4+ T helper cells. Nakanishi et al. report a previously unrecognized aspect of CD4 help in the CTL response: CD4+ T cells are required for the recruitment of CD8+ T cells to mucosal sites of viral infection. The CD4+ T-cell help requires the secretion of interferon-γ and the induction of local chemokine secretion.

Suggested Citation

  • Yusuke Nakanishi & Bao Lu & Craig Gerard & Akiko Iwasaki, 2009. "CD8+ T lymphocyte mobilization to virus-infected tissue requires CD4+ T-cell help," Nature, Nature, vol. 462(7272), pages 510-513, November.
    • Handle: RePEc:nat:nature:v:462:y:2009:i:7272:d:10.1038_nature08511
    DOI: 10.1038/nature08511
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature08511
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature08511?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Kieran English & Rain Kwan & Lauren E. Holz & Claire McGuffog & Jelte M. M. Krol & Daryan Kempe & Tsuneyasu Kaisho & William R. Heath & Leszek Lisowski & Maté Biro & Geoffrey W. McCaughan & David G. B, 2024. "A hepatic network of dendritic cells mediates CD4 T cell help outside lymphoid organs," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:462:y:2009:i:7272:d:10.1038_nature08511. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.