IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v462y2009i7270d10.1038_nature08529.html
   My bibliography  Save this article

Uptake through glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune response

Author

Listed:
  • Koji Hase

    (Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology, RIKEN, Kanagawa 230-0045, Japan)

  • Kazuya Kawano

    (Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology, RIKEN, Kanagawa 230-0045, Japan)

  • Tomonori Nochi

    (The Institute of Medical Science, The University of Tokyo)

  • Gemilson Soares Pontes

    (The Institute of Medical Science, The University of Tokyo)

  • Shinji Fukuda

    (Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology, RIKEN, Kanagawa 230-0045, Japan
    Supramolecular Biology, International Graduate School of Bionanoscience, Yokohama City University)

  • Masashi Ebisawa

    (Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology, RIKEN, Kanagawa 230-0045, Japan
    Supramolecular Biology, International Graduate School of Bionanoscience, Yokohama City University)

  • Kazunori Kadokura

    (Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology, RIKEN, Kanagawa 230-0045, Japan
    Supramolecular Biology, International Graduate School of Bionanoscience, Yokohama City University)

  • Toru Tobe

    (Graduate School of Medicine, Osaka University, 565-0871 Suita, Osaka, Japan)

  • Yumiko Fujimura

    (Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology, RIKEN, Kanagawa 230-0045, Japan)

  • Sayaka Kawano

    (Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology, RIKEN, Kanagawa 230-0045, Japan)

  • Atsuko Yabashi

    (Fukushima Medical University, School of Medicine)

  • Satoshi Waguri

    (Fukushima Medical University, School of Medicine)

  • Gaku Nakato

    (Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology, RIKEN, Kanagawa 230-0045, Japan
    Supramolecular Biology, International Graduate School of Bionanoscience, Yokohama City University)

  • Shunsuke Kimura

    (Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology, RIKEN, Kanagawa 230-0045, Japan)

  • Takaya Murakami

    (Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology, RIKEN, Kanagawa 230-0045, Japan)

  • Mitsutoshi Iimura

    (Institute of Gastroenterology, Tokyo Women’s Medical University)

  • Kimiyo Hamura

    (Institute of Gastroenterology, Tokyo Women’s Medical University)

  • Shin-Ichi Fukuoka

    (College of Science and Engineering, Aoyama Gakuin University, Kanagawa, 229-8558, Japan)

  • Anson W. Lowe

    (Stanford University, Stanford, California 94305, USA)

  • Kikuji Itoh

    (Veterinary Public Health, Graduate School of Agricultural and Life Sciences, The University of Tokyo)

  • Hiroshi Kiyono

    (The Institute of Medical Science, The University of Tokyo)

  • Hiroshi Ohno

    (Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology, RIKEN, Kanagawa 230-0045, Japan
    Supramolecular Biology, International Graduate School of Bionanoscience, Yokohama City University)

Abstract

M cells in immunity The mucosal immune system plays a major role in protecting mucosal surfaces against pathogens and also in promoting co-habitation with commensal microflora. To evoke the mucosal immune response, antigens on the mucosal surface must first cross the impermeable epithelial barrier into lymphoid structures such as Peyer's patches. This function, called antigen transcytosis, is thought to be mediated mainly by M cells, specialized epithelial cells in the Peyer's patches. A study of the mechanisms underlying antigen transcytosis by M cells shows that glycoprotein-2, expressed on the apical side of intestinal M cells, is the transcytotic receptor for bacteria expressing the FimH antigen. As M cells are considered a promising target for various oral vaccinations, this work points to glycoprotein-2-dependent transcytosis as a possible vaccine target.

Suggested Citation

  • Koji Hase & Kazuya Kawano & Tomonori Nochi & Gemilson Soares Pontes & Shinji Fukuda & Masashi Ebisawa & Kazunori Kadokura & Toru Tobe & Yumiko Fujimura & Sayaka Kawano & Atsuko Yabashi & Satoshi Wagur, 2009. "Uptake through glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune response," Nature, Nature, vol. 462(7270), pages 226-230, November.
    • Handle: RePEc:nat:nature:v:462:y:2009:i:7270:d:10.1038_nature08529
    DOI: 10.1038/nature08529
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature08529
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature08529?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Timothy F. Shay & Seongmin Jang & Tyler J. Brittain & Xinhong Chen & Beth Walker & Claire Tebbutt & Yujie Fan & Damien A. Wolfe & Cynthia M. Arokiaraj & Erin E. Sullivan & Xiaozhe Ding & Ting-Yu Wang , 2024. "Human cell surface-AAV interactomes identify LRP6 as blood-brain barrier transcytosis receptor and immune cytokine IL3 as AAV9 binder," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:462:y:2009:i:7270:d:10.1038_nature08529. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.