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Bidirectional plasticity in fast-spiking GABA circuits by visual experience

Author

Listed:
  • Yoko Yazaki-Sugiyama

    (CREST, JST, Toyonaka, Osaka 560-0082, Japan
    Laboratory for Neuronal Circuit Development,)

  • Siu Kang

    (Laboratory for Neural Circuit Theory, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan)

  • Hideyuki Câteau

    (Laboratory for Neural Circuit Theory, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan)

  • Tomoki Fukai

    (Laboratory for Neural Circuit Theory, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan)

  • Takao K. Hensch

    (CREST, JST, Toyonaka, Osaka 560-0082, Japan
    Laboratory for Neuronal Circuit Development,
    Present address: Center for Brain Science, Harvard University, 52 Oxford Street, Cambridge, Massachusetts 02138, USA.)

Abstract

How visual experience influences the brain Experience can induce robust plasticity in brain areas processing sensory information, but the influence of modified individual circuit elements on the network as a whole is largely unknown. New experiments analysed activity from within individual cells in parts of the visual circuit and found that upon monocular deprivation, cells initially bias their response preference toward the occluded eye, and only later shift to the open eye. This seemed to occur due to the ever-shifting balance between excitation and inhibition modulating the activity of individual neurons. Thus, inhibitory circuits play a major role in shaping experience-dependent plasticity in the developing visual cortex.

Suggested Citation

  • Yoko Yazaki-Sugiyama & Siu Kang & Hideyuki Câteau & Tomoki Fukai & Takao K. Hensch, 2009. "Bidirectional plasticity in fast-spiking GABA circuits by visual experience," Nature, Nature, vol. 462(7270), pages 218-221, November.
    • Handle: RePEc:nat:nature:v:462:y:2009:i:7270:d:10.1038_nature08485
    DOI: 10.1038/nature08485
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    Cited by:

    1. Manoj Kumar & Gregory Handy & Stylianos Kouvaros & Yanjun Zhao & Lovisa Ljungqvist Brinson & Eric Wei & Brandon Bizup & Brent Doiron & Thanos Tzounopoulos, 2023. "Cell-type-specific plasticity of inhibitory interneurons in the rehabilitation of auditory cortex after peripheral damage," Nature Communications, Nature, vol. 14(1), pages 1-23, December.

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