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Sleep deprivation impairs cAMP signalling in the hippocampus

Author

Listed:
  • Christopher G. Vecsey

    (Neuroscience Graduate Group,
    University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA)

  • George S. Baillie

    (Neuroscience and Molecular Pharmacology, Wolfson and Davidson Buildings, Faculty of Biomedical and Life Sciences, University of Glasgow)

  • Devan Jaganath

    (University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA)

  • Robbert Havekes

    (University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA)

  • Andrew Daniels

    (University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA)

  • Mathieu Wimmer

    (Neuroscience Graduate Group,
    University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA)

  • Ted Huang

    (Neuroscience Graduate Group,
    University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA)

  • Kim M. Brown

    (Neuroscience and Molecular Pharmacology, Wolfson and Davidson Buildings, Faculty of Biomedical and Life Sciences, University of Glasgow)

  • Xiang-Yao Li

    (University of Toronto, 1 King’s College Circle, Toronto, Ontario M5S 1A8, Canada)

  • Giannina Descalzi

    (University of Toronto, 1 King’s College Circle, Toronto, Ontario M5S 1A8, Canada)

  • Susan S. Kim

    (University of Toronto, 1 King’s College Circle, Toronto, Ontario M5S 1A8, Canada)

  • Tao Chen

    (University of Toronto, 1 King’s College Circle, Toronto, Ontario M5S 1A8, Canada)

  • Yu-Ze Shang

    (University of Toronto, 1 King’s College Circle, Toronto, Ontario M5S 1A8, Canada)

  • Min Zhuo

    (University of Toronto, 1 King’s College Circle, Toronto, Ontario M5S 1A8, Canada)

  • Miles D. Houslay

    (Neuroscience and Molecular Pharmacology, Wolfson and Davidson Buildings, Faculty of Biomedical and Life Sciences, University of Glasgow)

  • Ted Abel

    (University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA)

Abstract

Lost sleep, found memories It is well known that sleep deprivation can have cognitive consequences, including learning and memory deficits, but the mechanisms by which sleep deprivation affects brain function remain unknown. New experiments identify the cyclic AMP pathway as a functional target of sleep deprivation, specifically the impairment of cAMP/PKA-based plasticity in the hippocampus. Rescuing cAMP signalling using phosphodiesterase inhibitors also rescues the memory deficits, pointing to cAMP/PKA signalling enhancers as a possible therapeutic approach to counteract the cognitive effects of lost sleep.

Suggested Citation

  • Christopher G. Vecsey & George S. Baillie & Devan Jaganath & Robbert Havekes & Andrew Daniels & Mathieu Wimmer & Ted Huang & Kim M. Brown & Xiang-Yao Li & Giannina Descalzi & Susan S. Kim & Tao Chen &, 2009. "Sleep deprivation impairs cAMP signalling in the hippocampus," Nature, Nature, vol. 461(7267), pages 1122-1125, October.
    • Handle: RePEc:nat:nature:v:461:y:2009:i:7267:d:10.1038_nature08488
    DOI: 10.1038/nature08488
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    Cited by:

    1. Kosha J. Mehta, 2022. "Effect of sleep and mood on academic performance—at interface of physiology, psychology, and education," Palgrave Communications, Palgrave Macmillan, vol. 9(1), pages 1-13, December.
    2. Yann Vanrobaeys & Zeru J. Peterson & Emily. N. Walsh & Snehajyoti Chatterjee & Li-Chun Lin & Lisa C. Lyons & Thomas Nickl-Jockschat & Ted Abel, 2023. "Spatial transcriptomics reveals unique gene expression changes in different brain regions after sleep deprivation," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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