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Neuroscience in the era of functional genomics and systems biology

Author

Listed:
  • Daniel H. Geschwind

    (Program in Neurogenetics and Neurobehavioural Genetics
    David Geffen School of Medicine, Los Angeles, California 90095, USA.)

  • Genevieve Konopka

    (Program in Neurogenetics and Neurobehavioural Genetics)

Abstract

Advances in genetics and genomics have fuelled a revolution in discovery-based, or hypothesis-generating, research that provides a powerful complement to the more directly hypothesis-driven molecular, cellular and systems neuroscience. Genetic and functional genomic studies have already yielded important insights into neuronal diversity and function, as well as disease. One of the most exciting and challenging frontiers in neuroscience involves harnessing the power of large-scale genetic, genomic and phenotypic data sets, and the development of tools for data integration and mining. Methods for network analysis and systems biology offer the promise of integrating these multiple levels of data, connecting molecular pathways to nervous system function.

Suggested Citation

  • Daniel H. Geschwind & Genevieve Konopka, 2009. "Neuroscience in the era of functional genomics and systems biology," Nature, Nature, vol. 461(7266), pages 908-915, October.
    • Handle: RePEc:nat:nature:v:461:y:2009:i:7266:d:10.1038_nature08537
    DOI: 10.1038/nature08537
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    Cited by:

    1. Tiffany C Armenta & Steve W Cole & Daniel H Geschwind & Daniel T Blumstein & Robert K Wayne, 2019. "Gene expression shifts in yellow-bellied marmots prior to natal dispersal," Behavioral Ecology, International Society for Behavioral Ecology, vol. 30(2), pages 267-277.
    2. Yuyan Cheng & Yuqin Yin & Alice Zhang & Alexander M. Bernstein & Riki Kawaguchi & Kun Gao & Kyra Potter & Hui-Ya Gilbert & Yan Ao & Jing Ou & Catherine J. Fricano-Kugler & Jeffrey L. Goldberg & Zhigan, 2022. "Transcription factor network analysis identifies REST/NRSF as an intrinsic regulator of CNS regeneration in mice," Nature Communications, Nature, vol. 13(1), pages 1-22, December.

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