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A secreted complement-control-related protein ensures acetylcholine receptor clustering

Author

Listed:
  • Marie Gendrel

    (ENS
    INSERM, U789, Biologie cellulaire de la synapse)

  • Georgia Rapti

    (ENS
    INSERM, U789, Biologie cellulaire de la synapse)

  • Janet E. Richmond

    (University of Illinois, Chicago, Illinois 60607, USA)

  • Jean-Louis Bessereau

    (ENS
    INSERM, U789, Biologie cellulaire de la synapse)

Abstract

Synapse organization link to CCP changes For nerves to communicate efficiently with their target cells, the sites of neurotransmitter release must be properly aligned with zones of higher receptor densities. Working on the genetically tractable worm Caenorhabditis elegans, Gendrel et al. show that muscle cells secrete the protein LEV-9, which in turn interacts with LEV-10 to control proper clustering of the acetylcholine receptor. Surprisingly, LEV-9's synaptic function relies on 'control complement protein' (CCP) domains, known until now for their possible involvement in the mammalian immune system. The many CCP proteins that are produced in the mammalian brain might similarly control synapse organization, rather than immune functions.

Suggested Citation

  • Marie Gendrel & Georgia Rapti & Janet E. Richmond & Jean-Louis Bessereau, 2009. "A secreted complement-control-related protein ensures acetylcholine receptor clustering," Nature, Nature, vol. 461(7266), pages 992-996, October.
    • Handle: RePEc:nat:nature:v:461:y:2009:i:7266:d:10.1038_nature08430
    DOI: 10.1038/nature08430
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    Cited by:

    1. Yoshifumi Sonobe & Jihad Aburas & Gopinath Krishnan & Andrew C. Fleming & Ghanashyam Ghadge & Priota Islam & Eleanor C. Warren & Yuanzheng Gu & Mark W. Kankel & André E. X. Brown & Evangelos Kiskinis , 2021. "A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation," Nature Communications, Nature, vol. 12(1), pages 1-17, December.

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