IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v461y2009i7265d10.1038_nature08489.html
   My bibliography  Save this article

Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution

Author

Listed:
  • Sohrab P. Shah

    (Molecular Oncology,
    Centre for Translational and Applied Genomics,)

  • Ryan D. Morin

    (Michael Smith Genome Sciences Centre, BC Cancer Agency, 675 West 10th Avenue, Vancouver V5Z 1L3, Canada)

  • Jaswinder Khattra

    (Molecular Oncology,)

  • Leah Prentice

    (Molecular Oncology,)

  • Trevor Pugh

    (Michael Smith Genome Sciences Centre, BC Cancer Agency, 675 West 10th Avenue, Vancouver V5Z 1L3, Canada)

  • Angela Burleigh

    (Molecular Oncology,)

  • Allen Delaney

    (Michael Smith Genome Sciences Centre, BC Cancer Agency, 675 West 10th Avenue, Vancouver V5Z 1L3, Canada)

  • Karen Gelmon

    (Medical Oncology, BC Cancer Agency, 600 West 10th Avenue, Vancouver V5Z 1L3, Canada)

  • Ryan Guliany

    (Molecular Oncology,)

  • Janine Senz

    (Centre for Translational and Applied Genomics,)

  • Christian Steidl

    (Centre for Translational and Applied Genomics,
    University of British Columbia, G227-2211 Wesbrook Mall, British Columbia, Vancouver V6T 2B5, Canada)

  • Robert A. Holt

    (Michael Smith Genome Sciences Centre, BC Cancer Agency, 675 West 10th Avenue, Vancouver V5Z 1L3, Canada)

  • Steven Jones

    (Michael Smith Genome Sciences Centre, BC Cancer Agency, 675 West 10th Avenue, Vancouver V5Z 1L3, Canada)

  • Mark Sun

    (Molecular Oncology,)

  • Gillian Leung

    (Molecular Oncology,)

  • Richard Moore

    (Michael Smith Genome Sciences Centre, BC Cancer Agency, 675 West 10th Avenue, Vancouver V5Z 1L3, Canada)

  • Tesa Severson

    (Michael Smith Genome Sciences Centre, BC Cancer Agency, 675 West 10th Avenue, Vancouver V5Z 1L3, Canada)

  • Greg A. Taylor

    (Michael Smith Genome Sciences Centre, BC Cancer Agency, 675 West 10th Avenue, Vancouver V5Z 1L3, Canada)

  • Andrew E. Teschendorff

    (Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK)

  • Kane Tse

    (Molecular Oncology,)

  • Gulisa Turashvili

    (Molecular Oncology,)

  • Richard Varhol

    (Michael Smith Genome Sciences Centre, BC Cancer Agency, 675 West 10th Avenue, Vancouver V5Z 1L3, Canada)

  • René L. Warren

    (Michael Smith Genome Sciences Centre, BC Cancer Agency, 675 West 10th Avenue, Vancouver V5Z 1L3, Canada)

  • Peter Watson

    (Deeley Research Centre, BC Cancer Agency)

  • Yongjun Zhao

    (Michael Smith Genome Sciences Centre, BC Cancer Agency, 675 West 10th Avenue, Vancouver V5Z 1L3, Canada)

  • Carlos Caldas

    (Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK)

  • David Huntsman

    (Centre for Translational and Applied Genomics,
    University of British Columbia, G227-2211 Wesbrook Mall, British Columbia, Vancouver V6T 2B5, Canada)

  • Martin Hirst

    (Michael Smith Genome Sciences Centre, BC Cancer Agency, 675 West 10th Avenue, Vancouver V5Z 1L3, Canada)

  • Marco A. Marra

    (Michael Smith Genome Sciences Centre, BC Cancer Agency, 675 West 10th Avenue, Vancouver V5Z 1L3, Canada)

  • Samuel Aparicio

    (Molecular Oncology,
    Centre for Translational and Applied Genomics,
    University of British Columbia, G227-2211 Wesbrook Mall, British Columbia, Vancouver V6T 2B5, Canada)

Abstract

A cancer evolves: heterogeneity and mutational evolution in a breast tumour Next-generation sequencing approaches have been used to investigate the genomes and transcriptomes of an oestrogen-receptor-α-positive metastatic lobular breast cancer from a patient — rather than from a cell line or xenograft — over a 9-year period between the diagnosis of the primary tumour and the appearance of metastasis. Comparison of the somatic non-synonymous coding mutations in the metastasis and the primary tumour of the same patient and the combined analysis of genome and transcriptome data provided insights into the mutational evolution that can occur with disease progression. The cover shows sequence elements of the HAUS3 locus, one of the genes found to be mutated in the tissue (shown in the background) from the primary lobular cancer used for this work.

Suggested Citation

  • Sohrab P. Shah & Ryan D. Morin & Jaswinder Khattra & Leah Prentice & Trevor Pugh & Angela Burleigh & Allen Delaney & Karen Gelmon & Ryan Guliany & Janine Senz & Christian Steidl & Robert A. Holt & Ste, 2009. "Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution," Nature, Nature, vol. 461(7265), pages 809-813, October.
    • Handle: RePEc:nat:nature:v:461:y:2009:i:7265:d:10.1038_nature08489
    DOI: 10.1038/nature08489
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature08489
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature08489?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Roland F Schwarz & Anne Trinh & Botond Sipos & James D Brenton & Nick Goldman & Florian Markowetz, 2014. "Phylogenetic Quantification of Intra-tumour Heterogeneity," PLOS Computational Biology, Public Library of Science, vol. 10(4), pages 1-11, April.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:461:y:2009:i:7265:d:10.1038_nature08489. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.