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JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin

Author

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  • Mark A. Dawson

    (University of Cambridge, Hills Road, Cambridge CB2 0XY, UK
    Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0QQ, UK)

  • Andrew J. Bannister

    (University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK)

  • Berthold Göttgens

    (University of Cambridge, Hills Road, Cambridge CB2 0XY, UK)

  • Samuel D. Foster

    (University of Cambridge, Hills Road, Cambridge CB2 0XY, UK)

  • Till Bartke

    (University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK)

  • Anthony R. Green

    (University of Cambridge, Hills Road, Cambridge CB2 0XY, UK
    Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0QQ, UK)

  • Tony Kouzarides

    (University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK)

Abstract

JAK2 kinase goes nuclear JAK2 is a non-receptor tyrosine kinase that regulates diverse cellular processes by inducing cytoplasmic signalling cascades. Dawson et al. now report a previously unknown nuclear function for JAK2. Tyrosine phosphorylation of histone H3 by JAK2 can lead to disruption of HP1 α binding to chromatin and changes in gene expression. This finding is of particular interest because JAK2 inhibitors are in clinical trials for the treatment of myeloid leukaemias in which JAK2 is dysregulated.

Suggested Citation

  • Mark A. Dawson & Andrew J. Bannister & Berthold Göttgens & Samuel D. Foster & Till Bartke & Anthony R. Green & Tony Kouzarides, 2009. "JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin," Nature, Nature, vol. 461(7265), pages 819-822, October.
    • Handle: RePEc:nat:nature:v:461:y:2009:i:7265:d:10.1038_nature08448
    DOI: 10.1038/nature08448
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    Cited by:

    1. Surbhi Chouhan & Dhivya Sridaran & Cody Weimholt & Jingqin Luo & Tiandao Li & Myles C. Hodgson & Luana N. Santos & Samantha Sommer & Bin Fang & John M. Koomen & Markus Seeliger & Cheng-Kui Qu & Armell, 2024. "SHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54 to amend androgen receptor homeostasis," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Hidehiro Itonaga & Adnan K. Mookhtiar & Sarah M. Greenblatt & Fan Liu & Concepcion Martinez & Daniel Bilbao & Masai Rains & Pierre-Jacques Hamard & Jun Sun & Afoma C. Umeano & Stephanie Duffort & Chua, 2024. "Tyrosine phosphorylation of CARM1 promotes its enzymatic activity and alters its target specificity," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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