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Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules

Author

Listed:
  • Shuizi Rachel Yu

    (Developmental Genetics, Biotechnology Center, TUD,
    Center for Regenerative Therapies, TUD, Tatzberg 47-49, 01307 Dresden, Germany)

  • Markus Burkhardt

    (Biophysics, Biotechnology Center, TUD, and,
    Center for Regenerative Therapies, TUD, Tatzberg 47-49, 01307 Dresden, Germany)

  • Matthias Nowak

    (Developmental Genetics, Biotechnology Center, TUD,
    Center for Regenerative Therapies, TUD, Tatzberg 47-49, 01307 Dresden, Germany)

  • Jonas Ries

    (Biophysics, Biotechnology Center, TUD, and,
    Center for Regenerative Therapies, TUD, Tatzberg 47-49, 01307 Dresden, Germany)

  • Zdeněk Petrášek

    (Biophysics, Biotechnology Center, TUD, and,
    Center for Regenerative Therapies, TUD, Tatzberg 47-49, 01307 Dresden, Germany)

  • Steffen Scholpp

    (Developmental Genetics, Biotechnology Center, TUD,
    Present address: Institute of Toxicology and Genetics, Forschungszentrum Karlsruhe, D-76021 Karlsruhe, Germany.)

  • Petra Schwille

    (Biophysics, Biotechnology Center, TUD, and,
    Center for Regenerative Therapies, TUD, Tatzberg 47-49, 01307 Dresden, Germany)

  • Michael Brand

    (Developmental Genetics, Biotechnology Center, TUD,
    Center for Regenerative Therapies, TUD, Tatzberg 47-49, 01307 Dresden, Germany)

Abstract

Morphogens keep it simple Concentration gradients of certain molecules termed 'morphogens' are known to control tissue development during embryogenesis. Yu et al. have addressed the little understood question of how such gradients form. They use an advanced and highly precise technology for imaging molecules in vivo (fluorescence correlation spectroscopy) to show that freely diffusing Fgf8 morphogen gradients in living zebrafish embryos arise from a simple source–sink mechanism.

Suggested Citation

  • Shuizi Rachel Yu & Markus Burkhardt & Matthias Nowak & Jonas Ries & Zdeněk Petrášek & Steffen Scholpp & Petra Schwille & Michael Brand, 2009. "Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules," Nature, Nature, vol. 461(7263), pages 533-536, September.
    • Handle: RePEc:nat:nature:v:461:y:2009:i:7263:d:10.1038_nature08391
    DOI: 10.1038/nature08391
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    Cited by:

    1. Roman Vetter & Dagmar Iber, 2022. "Precision of morphogen gradients in neural tube development," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Fabian Gude & Jurij Froese & Dominique Manikowski & Daniele Di Iorio & Jean-Noël Grad & Seraphine Wegner & Daniel Hoffmann & Melissa Kennedy & Ralf P. Richter & Georg Steffes & Kay Grobe, 2023. "Hedgehog is relayed through dynamic heparan sulfate interactions to shape its gradient," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Timo Kuhn & Amit N. Landge & David Mörsdorf & Jonas Coßmann & Johanna Gerstenecker & Daniel Čapek & Patrick Müller & J. Christof M. Gebhardt, 2022. "Single-molecule tracking of Nodal and Lefty in live zebrafish embryos supports hindered diffusion model," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    4. R. Allena & J. Muñoz & D. Aubry, 2013. "Diffusion-reaction model for embryo development," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 16(3), pages 235-248.

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