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Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation

Author

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  • Edward Owusu-Ansah

    (Cell and Developmental Biology
    Present address: Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.)

  • Utpal Banerjee

    (Cell and Developmental Biology
    Molecular Biology Institute,
    Department of Biological Chemistry,
    Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, California 90095, USA)

Abstract

Reactive oxygen's good side While largely studied because of their harmful effects in DNA damage, protein/lipid oxidation and apoptosis, there is a growing appreciation that reactive oxygen species (ROS) may have beneficial effects in some tissues. In the mammalian haematopoietic system, haematopoietic stem cells contain low ROS levels, but unexpectedly, the common myeloid progenitors (CMPs), produce significantly elevated levels of ROS. Edward Owusu-Ansah and Utpal Banerjee have discovered the apparent functional significance of this difference in ROS level in the two progenitor types in Drosophila. They show that the developmentally regulated, moderately high ROS level in the progenitor population sensitizes them to differentiation, and establishes a signalling role for ROS in the regulation of haematopoietic cell fate.

Suggested Citation

  • Edward Owusu-Ansah & Utpal Banerjee, 2009. "Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation," Nature, Nature, vol. 461(7263), pages 537-541, September.
    • Handle: RePEc:nat:nature:v:461:y:2009:i:7263:d:10.1038_nature08313
    DOI: 10.1038/nature08313
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    Cited by:

    1. Wen Shi & Lingyan Wang & Lianmei Yao & Wei Hao & Chao Han & Min Fan & Wenfei Wang & Ming-Yi Bai, 2022. "Spatially patterned hydrogen peroxide orchestrates stomatal development in Arabidopsis," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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