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Kaplan et al. reply

Author

Listed:
  • Rosandra N. Kaplan

    (Department of Pediatrics and the Children’s Blood Foundation Laboratories,
    Cell and Developmental Biology,
    Department of Pediatrics and)

  • Rebecca D. Riba

    (Department of Pediatrics and the Children’s Blood Foundation Laboratories,
    Cell and Developmental Biology,)

  • Stergios Zacharoulis

    (Department of Pediatrics and the Children’s Blood Foundation Laboratories,
    Cell and Developmental Biology,
    Department of Pediatrics and)

  • Anna H. Bramley

    (Department of Pediatrics and the Children’s Blood Foundation Laboratories,
    Cell and Developmental Biology,)

  • Loïc Vincent

    (Genetic Medicine and)

  • Carla Costa

    (Department of Pediatrics and the Children’s Blood Foundation Laboratories,
    Cell and Developmental Biology,)

  • Daniel D. MacDonald

    (Department of Pediatrics and the Children’s Blood Foundation Laboratories,
    Cell and Developmental Biology,)

  • David K. Jin

    (Genetic Medicine and)

  • Koji Shido

    (Genetic Medicine and)

  • Scott A. Kerns

    (Department of Pediatrics and the Children’s Blood Foundation Laboratories,
    Cell and Developmental Biology,)

  • Zhenping Zhu

    (Imclone Systems Incorporated)

  • Daniel Hicklin

    (Imclone Systems Incorporated)

  • Yan Wu

    (Imclone Systems Incorporated)

  • Jeffrey L. Port

    (‖ Surgery, Weill Cornell Medical College of Cornell University, 1300 York Avenue and)

  • Nasser Altorki

    (‖ Surgery, Weill Cornell Medical College of Cornell University, 1300 York Avenue and)

  • Elisa R. Port

    (# Surgery, Memorial Sloan-Kettering Cancer Center, 1233 York Avenue, New York, New York 10021, USA. dcl2001@med.cornell.edu)

  • Davide Ruggero

    (Fox Chase Cancer Center)

  • Sergey V. Shmelkov

    (Department of Pediatrics and the Children’s Blood Foundation Laboratories,
    Cell and Developmental Biology,
    Genetic Medicine and)

  • Kristian K. Jensen

    (Department of Pediatrics and the Children’s Blood Foundation Laboratories,
    Cell and Developmental Biology,)

  • Shahin Rafii

    (Howard Hughes Medical Institute,
    Genetic Medicine and)

  • David Lyden

    (Department of Pediatrics and the Children’s Blood Foundation Laboratories,
    Cell and Developmental Biology,
    Department of Pediatrics and)

  • J. Wels

    (Department of Pediatrics and the Children’s Blood Foundation Laboratories,
    Cell and Developmental Biology,
    Extra author)

Abstract

Replying to: M. R. Dawson et al. Nature 461, 10.1038/nature08254 (2009) Commenting on ref. 1, Dawson et al. 2 claim that metastasis formation is independent of VEGFR1 activity, contradicting work by us and many others, including the original description of flt1TK-/- (VEGFR1-TK-/-) mice in the metastatic setting3. Contrasting the findings by Dawson et al.2, here we show that VEGFR1 knockdown in myelomonocytic cells eradicates micro- and macrometastases in a non-amputation/resection tumour model.

Suggested Citation

  • Rosandra N. Kaplan & Rebecca D. Riba & Stergios Zacharoulis & Anna H. Bramley & Loïc Vincent & Carla Costa & Daniel D. MacDonald & David K. Jin & Koji Shido & Scott A. Kerns & Zhenping Zhu & Daniel Hi, 2009. "Kaplan et al. reply," Nature, Nature, vol. 461(7262), pages 5-5, September.
    • Handle: RePEc:nat:nature:v:461:y:2009:i:7262:d:10.1038_nature08261
    DOI: 10.1038/nature08261
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