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Genomic views of distant-acting enhancers

Author

Listed:
  • Axel Visel

    (MS 84–171, Lawrence Berkeley National Laboratory
    Walnut Creek)

  • Edward M. Rubin

    (MS 84–171, Lawrence Berkeley National Laboratory
    Walnut Creek)

  • Len A. Pennacchio

    (MS 84–171, Lawrence Berkeley National Laboratory
    Walnut Creek)

Abstract

In contrast to protein-coding sequences, the significance of variation in non-coding DNA in human disease has been minimally explored. A great number of recent genome-wide association studies suggest that non-coding variation is a significant risk factor for common disorders, but the mechanisms by which this variation contributes to disease remain largely obscure. Distant-acting transcriptional enhancers — a major category of functional non-coding DNA — are involved in many developmental and disease-relevant processes. Genome-wide approaches to their discovery and functional characterization are now available and provide a growing knowledge base for the systematic exploration of their role in human biology and disease susceptibility.

Suggested Citation

  • Axel Visel & Edward M. Rubin & Len A. Pennacchio, 2009. "Genomic views of distant-acting enhancers," Nature, Nature, vol. 461(7261), pages 199-205, September.
    • Handle: RePEc:nat:nature:v:461:y:2009:i:7261:d:10.1038_nature08451
    DOI: 10.1038/nature08451
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    Cited by:

    1. Christopher G Bell & Sarah Finer & Cecilia M Lindgren & Gareth A Wilson & Vardhman K Rakyan & Andrew E Teschendorff & Pelin Akan & Elia Stupka & Thomas A Down & Inga Prokopenko & Ian M Morison & Jonat, 2010. "Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus," PLOS ONE, Public Library of Science, vol. 5(11), pages 1-12, November.
    2. Julien Broséus & Sébastien Hergalant & Julia Vogt & Eugen Tausch & Markus Kreuz & Anja Mottok & Christof Schneider & Caroline Dartigeas & Damien Roos-Weil & Anne Quinquenel & Charline Moulin & German , 2023. "Molecular characterization of Richter syndrome identifies de novo diffuse large B-cell lymphomas with poor prognosis," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Jincai Yang & Huichao Gu & Xingpeng Jiang & Qingyang Huang & Xiaohua Hu & Xianjun Shen, 2017. "Identifying the Risky SNP of Osteoporosis with ID3-PEP Decision Tree Algorithm," Complexity, Hindawi, vol. 2017, pages 1-8, August.
    4. M S Vijayabaskar & Debbie K Goode & Nadine Obier & Monika Lichtinger & Amber M L Emmett & Fatin N Zainul Abidin & Nisar Shar & Rebecca Hannah & Salam A Assi & Michael Lie-A-Ling & Berthold Gottgens & , 2019. "Identification of gene specific cis-regulatory elements during differentiation of mouse embryonic stem cells: An integrative approach using high-throughput datasets," PLOS Computational Biology, Public Library of Science, vol. 15(11), pages 1-29, November.

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