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Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

Author

Listed:
  • Michael R. Elliott

    (Beirne B. Carter Center for Immunology Research,
    Center for Cell Clearance,)

  • Faraaz B. Chekeni

    (Beirne B. Carter Center for Immunology Research,
    Department of Pharmacology,)

  • Paul C. Trampont

    (Beirne B. Carter Center for Immunology Research,
    Center for Cell Clearance,)

  • Eduardo R. Lazarowski

    (Department of Medicine,)

  • Alexandra Kadl

    (Robert M. Berne Cardiovascular Research Center,)

  • Scott F. Walk

    (Beirne B. Carter Center for Immunology Research,
    Center for Cell Clearance,)

  • Daeho Park

    (Beirne B. Carter Center for Immunology Research,
    Center for Cell Clearance,)

  • Robin I. Woodson

    (Department of Urology,)

  • Marina Ostankovich

    (Robert M. Berne Cardiovascular Research Center,)

  • Poonam Sharma

    (Robert M. Berne Cardiovascular Research Center,)

  • Jeffrey J. Lysiak

    (Department of Urology,)

  • T. Kendall Harden

    (University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA)

  • Norbert Leitinger

    (Department of Pharmacology,
    Robert M. Berne Cardiovascular Research Center,)

  • Kodi S. Ravichandran

    (Beirne B. Carter Center for Immunology Research,
    Center for Cell Clearance,
    University of Virginia, Charlottesville, Virginia 22908, USA)

Abstract

Apoptosis: how cells become targets Apoptosis occurs in essentially all tissues as part of normal development and homeostasis. Yet even in tissues with high cellular turnover, apoptotic cells are rarely seen; this has been attributed to the ability of apoptotic cells to advertise their presence via release of 'find-me' signals to recruit phagocytes and initiate prompt clearance. It has been unclear, however, what type of find-me signals are released by apoptotic cells and how these are sensed by phagocytes. In this paper apoptotic cells are shown to release ATP and UTP that act as a 'find me ' signal and chemoattractant for phagocytes expressing the P2Y2 ATP/UTP receptor.

Suggested Citation

  • Michael R. Elliott & Faraaz B. Chekeni & Paul C. Trampont & Eduardo R. Lazarowski & Alexandra Kadl & Scott F. Walk & Daeho Park & Robin I. Woodson & Marina Ostankovich & Poonam Sharma & Jeffrey J. Lys, 2009. "Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance," Nature, Nature, vol. 461(7261), pages 282-286, September.
    • Handle: RePEc:nat:nature:v:461:y:2009:i:7261:d:10.1038_nature08296
    DOI: 10.1038/nature08296
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    Cited by:

    1. Mazen Shihan & Tatyana Novoyatleva & Thilo Lehmeyer & Akylbek Sydykov & Ralph T. Schermuly, 2021. "Role of the Purinergic P2Y2 Receptor in Pulmonary Hypertension," IJERPH, MDPI, vol. 18(21), pages 1-20, October.
    2. Michael S. Schappe & Marta E. Stremska & Gregory W. Busey & Taylor K. Downs & Philip V. Seegren & Suresh K. Mendu & Zachary Flegal & Catherine A. Doyle & Eric J. Stipes & Bimal N. Desai, 2022. "Efferocytosis requires periphagosomal Ca2+-signaling and TRPM7-mediated electrical activity," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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