IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v461y2009i7261d10.1038_nature08265.html
   My bibliography  Save this article

Co-translational mRNA decay in Saccharomyces cerevisiae

Author

Listed:
  • Wenqian Hu

    (Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, Ohio 44106, USA)

  • Thomas J. Sweet

    (Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, Ohio 44106, USA)

  • Sangpen Chamnongpol

    (Affymetrix Inc., 26111 Miles Road, Cleveland, Ohio 44128, USA)

  • Kristian E. Baker

    (Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, Ohio 44106, USA)

  • Jeff Coller

    (Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, Ohio 44106, USA)

Abstract

The rates of RNA decay and transcription determine the steady-state levels of all messenger RNA and both can be subject to regulation. Although the details of transcriptional regulation are becoming increasingly understood, the mechanism(s) controlling mRNA decay remain unclear. In yeast, a major pathway of mRNA decay begins with deadenylation followed by decapping and 5′–3′ exonuclease digestion. Importantly, it is hypothesized that ribosomes must be removed from mRNA before transcripts are destroyed. Contrary to this prediction, here we show that decay takes place while mRNAs are associated with actively translating ribosomes. The data indicate that dissociation of ribosomes from mRNA is not a prerequisite for decay and we suggest that the 5′–3′ polarity of mRNA degradation has evolved to ensure that the last translocating ribosome can complete translation.

Suggested Citation

  • Wenqian Hu & Thomas J. Sweet & Sangpen Chamnongpol & Kristian E. Baker & Jeff Coller, 2009. "Co-translational mRNA decay in Saccharomyces cerevisiae," Nature, Nature, vol. 461(7261), pages 225-229, September.
  • Handle: RePEc:nat:nature:v:461:y:2009:i:7261:d:10.1038_nature08265
    DOI: 10.1038/nature08265
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature08265
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/nature08265?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Tin-Lok Wong & Jia-Jian Loh & Shixun Lu & Helen H. N. Yan & Hoi Cheong Siu & Ren Xi & Dessy Chan & Max J. F. Kam & Lei Zhou & Man Tong & John A. Copland & Leilei Chen & Jing-Ping Yun & Suet Yi Leung &, 2023. "ADAR1-mediated RNA editing of SCD1 drives drug resistance and self-renewal in gastric cancer," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:461:y:2009:i:7261:d:10.1038_nature08265. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.