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Reptilian heart development and the molecular basis of cardiac chamber evolution

Author

Listed:
  • Kazuko Koshiba-Takeuchi

    (Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
    Department of Pediatrics,
    Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA
    Global-Edge Institute, Tokyo Institute of Technology, Yokohama, Kanagawa 226-8503, Japan)

  • Alessandro D. Mori

    (Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
    Department of Pediatrics,
    Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA
    Program in Stem Cell and Developmental Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada)

  • Bogac L. Kaynak

    (Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
    Department of Pediatrics,
    Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA)

  • Judith Cebra-Thomas

    (Millersville University, Millersville, Pennsylvania 17551, USA)

  • Tatyana Sukonnik

    (Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
    Department of Pediatrics,
    Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA)

  • Romain O. Georges

    (Institut de Recherches Cliniques de Montréal, Programme de Biologie Moléculaire, Université de Montréal, Montréal, Québec H3C 3J7, Canada)

  • Stephany Latham

    (Michigan State University, East Lansing, Michigan 48824, USA)

  • Laural Beck

    (Michigan State University, East Lansing, Michigan 48824, USA)

  • R. Mark Henkelman

    (The Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    University of Toronto, Toronto, Ontario M5S 1A8, Canada)

  • Brian L. Black

    (Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA
    University of California, San Francisco, California 94158, USA)

  • Eric N. Olson

    (University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA)

  • Juli Wade

    (Michigan State University, East Lansing, Michigan 48824, USA)

  • Jun K. Takeuchi

    (Global-Edge Institute, Tokyo Institute of Technology, Yokohama, Kanagawa 226-8503, Japan)

  • Mona Nemer

    (Institut de Recherches Cliniques de Montréal, Programme de Biologie Moléculaire, Université de Montréal, Montréal, Québec H3C 3J7, Canada
    Microbiology and Immunology, University of Ottawa, Ottawa, Ontario K1H 8M5 Canada)

  • Scott F. Gilbert

    (Swarthmore College, Swarthmore, Pennsylvania 19081, USA)

  • Benoit G. Bruneau

    (Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
    Department of Pediatrics,
    Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA
    Program in Stem Cell and Developmental Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada)

Abstract

Heart to heart Birds, mammals and crocodiles have hearts with two separate ventricles, servicing separate pulmonary and systemic circulations. Amphibians have just one ventricle, but in most reptiles, the situation is unclear. A new embryological study of a lizard (the green anole) and a turtle (the slider turtle) shows that the division of an ancestral single ventricle into two chambers is related to the expression of the T-box transcription factor Tbx5. In embryonic birds and mammals, Tbx5 expression is restricted to precursors of the left ventricle. In turtles and lizards, Tbx5 is initially expressed throughout the ventricle, but in turtles (though not lizards) it is later restricted to the left side of the chamber. This identifies altered Tbx5 expression as a possible evolutionary force driving embryonic heart patterning to provide the key adaptation to high-energy terrestrial life, the fully septated heart. In line with this idea, mice in which Tbx5 function is lost or expanded develop a single chamber lacking distinct identity.

Suggested Citation

  • Kazuko Koshiba-Takeuchi & Alessandro D. Mori & Bogac L. Kaynak & Judith Cebra-Thomas & Tatyana Sukonnik & Romain O. Georges & Stephany Latham & Laural Beck & R. Mark Henkelman & Brian L. Black & Eric , 2009. "Reptilian heart development and the molecular basis of cardiac chamber evolution," Nature, Nature, vol. 461(7260), pages 95-98, September.
    • Handle: RePEc:nat:nature:v:461:y:2009:i:7260:d:10.1038_nature08324
    DOI: 10.1038/nature08324
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    Cited by:

    1. Clara Guijarro & Solène Song & Benoit Aigouy & Raphaël Clément & Paul Villoutreix & Robert G. Kelly, 2024. "Single-cell morphometrics reveals T-box gene-dependent patterns of epithelial tension in the Second Heart field," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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