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The Ink4/Arf locus is a barrier for iPS cell reprogramming

Author

Listed:
  • Han Li

    (Tumor Suppression Group,)

  • Manuel Collado

    (Tumor Suppression Group,)

  • Aranzazu Villasante

    (Tumor Suppression Group,)

  • Katerina Strati

    (Telomeres and Telomerase Group,)

  • Sagrario Ortega

    (Transgenic Mice Unit,)

  • Marta Cañamero

    (Comparative Pathology Unit, Spanish National Cancer Research Centre (CNIO), 3 Melchor Fernandez Almagro Street, Madrid E-28029, Spain)

  • Maria A. Blasco

    (Telomeres and Telomerase Group,)

  • Manuel Serrano

    (Tumor Suppression Group,)

Abstract

On iPS cells and p53: the Ink4/Arf barrier The Ink4/Arf tumour suppressor locus encodes three potent tumour suppressors, namely p16Ink4a, p15Ink4b and p19Arf. Here Li et al. show that the locus is rate limiting for reprogramming, and its transient inhibition significantly improves the generation of iPS cells. The also show ageing upregulates the Ink4/Arf locus and, accordingly, reprogramming is less efficient in cells from old organisms.

Suggested Citation

  • Han Li & Manuel Collado & Aranzazu Villasante & Katerina Strati & Sagrario Ortega & Marta Cañamero & Maria A. Blasco & Manuel Serrano, 2009. "The Ink4/Arf locus is a barrier for iPS cell reprogramming," Nature, Nature, vol. 460(7259), pages 1136-1139, August.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7259:d:10.1038_nature08290
    DOI: 10.1038/nature08290
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    Cited by:

    1. Daniel F. Kaemena & Masahito Yoshihara & Meryam Beniazza & James Ashmore & Suling Zhao & Mårten Bertenstam & Victor Olariu & Shintaro Katayama & Keisuke Okita & Simon R. Tomlinson & Kosuke Yusa & Keis, 2023. "B1 SINE-binding ZFP266 impedes mouse iPSC generation through suppression of chromatin opening mediated by reprogramming factors," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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