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Metalloproteins and metal sensing

Author

Listed:
  • Kevin J. Waldron

    (Cell & Molecular Biosciences, Medical School, Newcastle University)

  • Julian C. Rutherford

    (Cell & Molecular Biosciences, Medical School, Newcastle University)

  • Dianne Ford

    (Cell & Molecular Biosciences, Medical School, Newcastle University)

  • Nigel J. Robinson

    (Cell & Molecular Biosciences, Medical School, Newcastle University)

Abstract

Almost half of all enzymes must associate with a particular metal to function. An ambition is to understand why each metal–protein partnership arose and how it is maintained. Metal availability provides part of the explanation, and has changed over geological time and varies between habitats but is held within vital limits in cells. Such homeostasis needs metal sensors, and there is an ongoing search to discover the metal-sensing mechanisms. For metalloproteins to acquire the right metals, metal sensors must correctly distinguish between the inorganic elements.

Suggested Citation

  • Kevin J. Waldron & Julian C. Rutherford & Dianne Ford & Nigel J. Robinson, 2009. "Metalloproteins and metal sensing," Nature, Nature, vol. 460(7257), pages 823-830, August.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7257:d:10.1038_nature08300
    DOI: 10.1038/nature08300
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    Cited by:

    1. Anirban Goutam Mukherjee & Kaviyarasi Renu & Abilash Valsala Gopalakrishnan & Vishnu Priya Veeraraghavan & Sathishkumar Vinayagam & Soraya Paz-Montelongo & Abhijit Dey & Balachandar Vellingiri & Alex , 2023. "Heavy Metal and Metalloid Contamination in Food and Emerging Technologies for Its Detection," Sustainability, MDPI, vol. 15(2), pages 1-30, January.
    2. Jutta Diessl & Jens Berndtsson & Filomena Broeskamp & Lukas Habernig & Verena Kohler & Carmela Vazquez-Calvo & Arpita Nandy & Carlotta Peselj & Sofia Drobysheva & Ludovic Pelosi & F.-Nora Vögtle & Fab, 2022. "Manganese-driven CoQ deficiency," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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