IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v460y2009i7257d10.1038_nature08196.html
   My bibliography  Save this article

Multiple roles for MRE11 at uncapped telomeres

Author

Listed:
  • Yibin Deng

    (Box 1010
    Present address: Section of Cancer Genetics, The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA.)

  • Xiaolan Guo

    (Box 1010
    Institute of Rheumatology and Immunology North Sichuan Medical College, Nanchong, Sichuan 637000, China
    Present address: Section of Cancer Genetics, The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA.)

  • David O. Ferguson

    (The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA)

  • Sandy Chang

    (Box 1010
    The M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA)

Abstract

Protecting the telomere: a complex tale The ends of linear eukaryotic chromosomes are capped by sequences known as telomeres. Although these are essentially one half of a DNA double-strand break, which is a pathogenic lesion that must be repaired to maintain the genome's integrity, telomeres do not normally activate DNA damage repair pathways. A major player in the process of telomere maintenance is the MRN complex, made up of three proteins (MRE11, RAD50 and NBS1). Now a study in mice using alleles that inactivate either the whole MRN complex or just the nuclease activity of MRE1, shows that MRE11 serves two functions at the telomere. It protects newly synthesized telomeric ends from repair factors by promoting the formation of an overhanging DNA end, and it degrades the overhang to promote fusion repair when the telomere is not functioning properly.

Suggested Citation

  • Yibin Deng & Xiaolan Guo & David O. Ferguson & Sandy Chang, 2009. "Multiple roles for MRE11 at uncapped telomeres," Nature, Nature, vol. 460(7257), pages 914-918, August.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7257:d:10.1038_nature08196
    DOI: 10.1038/nature08196
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature08196
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature08196?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Haichao Zhao & Jia Li & Zhongsheng You & Howard D. Lindsay & Shan Yan, 2024. "Distinct regulation of ATM signaling by DNA single-strand breaks and APE1," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Zeliha Yalçin & Shiu Yeung Lam & Marieke H. Peuscher & Jaco Torre & Sha Zhu & Prasanna V. Iyengar & Daniel Salas-Lloret & Inge Krijger & Nathalie Moatti & Ruben Lugt & Mattia Falcone & Aurora Cerutti , 2024. "UBE2D3 facilitates NHEJ by orchestrating ATM signalling through multi-level control of RNF168," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:460:y:2009:i:7257:d:10.1038_nature08196. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.