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Multiple roles for MRE11 at uncapped telomeres

Author

Listed:
  • Yibin Deng

    (Box 1010
    Present address: Section of Cancer Genetics, The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA.)

  • Xiaolan Guo

    (Box 1010
    Institute of Rheumatology and Immunology North Sichuan Medical College, Nanchong, Sichuan 637000, China
    Present address: Section of Cancer Genetics, The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA.)

  • David O. Ferguson

    (The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA)

  • Sandy Chang

    (Box 1010
    The M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA)

Abstract

Protecting the telomere: a complex tale The ends of linear eukaryotic chromosomes are capped by sequences known as telomeres. Although these are essentially one half of a DNA double-strand break, which is a pathogenic lesion that must be repaired to maintain the genome's integrity, telomeres do not normally activate DNA damage repair pathways. A major player in the process of telomere maintenance is the MRN complex, made up of three proteins (MRE11, RAD50 and NBS1). Now a study in mice using alleles that inactivate either the whole MRN complex or just the nuclease activity of MRE1, shows that MRE11 serves two functions at the telomere. It protects newly synthesized telomeric ends from repair factors by promoting the formation of an overhanging DNA end, and it degrades the overhang to promote fusion repair when the telomere is not functioning properly.

Suggested Citation

  • Yibin Deng & Xiaolan Guo & David O. Ferguson & Sandy Chang, 2009. "Multiple roles for MRE11 at uncapped telomeres," Nature, Nature, vol. 460(7257), pages 914-918, August.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7257:d:10.1038_nature08196
    DOI: 10.1038/nature08196
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    Cited by:

    1. Zeliha Yalçin & Shiu Yeung Lam & Marieke H. Peuscher & Jaco Torre & Sha Zhu & Prasanna V. Iyengar & Daniel Salas-Lloret & Inge Krijger & Nathalie Moatti & Ruben Lugt & Mattia Falcone & Aurora Cerutti , 2024. "UBE2D3 facilitates NHEJ by orchestrating ATM signalling through multi-level control of RNF168," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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