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Common variants on chromosome 6p22.1 are associated with schizophrenia

Author

Listed:
  • Jianxin Shi

    (Stanford University, Stanford, California 94304, USA)

  • Douglas F. Levinson

    (Stanford University, Stanford, California 94304, USA)

  • Jubao Duan

    (Center for Psychiatric Genetics, NorthShore University HealthSystem Research Institute, Evanston, Illinois 60201, USA)

  • Alan R. Sanders

    (Center for Psychiatric Genetics, NorthShore University HealthSystem Research Institute, Evanston, Illinois 60201, USA)

  • Yonglan Zheng

    (Center for Psychiatric Genetics, NorthShore University HealthSystem Research Institute, Evanston, Illinois 60201, USA)

  • Itsik Pe’er

    (Columbia University, New York, New York 10027, USA)

  • Frank Dudbridge

    (Medical Research Council-Biostatistics Unit, Institute of Public Health)

  • Peter A. Holmans

    (MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Heath Park, Cardiff CF23 6BQ, UK)

  • Alice S. Whittemore

    (Stanford University, Stanford, California 94304, USA)

  • Bryan J. Mowry

    (Queensland Centre for Mental Health Research, and Queensland Institute for Medical Research, Brisbane, Queensland 4072, Australia)

  • Ann Olincy

    (University of Colorado Denver, Aurora, Colorado 80045, USA)

  • Farooq Amin

    (Atlanta Veterans Affairs Medical Center, and Emory University, Atlanta, Georgia 30322, USA)

  • C. Robert Cloninger

    (Washington University, St Louis, Missouri 63110, USA)

  • Jeremy M. Silverman

    (Mount Sinai School of Medicine, New York, New York 10029, USA)

  • Nancy G. Buccola

    (School of Nursing, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA)

  • William F. Byerley

    (University of California at San Francisco, San Francisco, California 94143, USA)

  • Donald W. Black

    (Mental Health Clinical Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA)

  • Raymond R. Crowe

    (Mental Health Clinical Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA)

  • Jorge R. Oksenberg

    (School of Medicine, University of California at San Francisco, San Francisco, California 94143, USA)

  • Daniel B. Mirel

    (Center for Genotyping and Analysis, Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA)

  • Kenneth S. Kendler

    (and Human Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA)

  • Robert Freedman

    (University of Colorado Denver, Aurora, Colorado 80045, USA)

  • Pablo V. Gejman

    (Center for Psychiatric Genetics, NorthShore University HealthSystem Research Institute, Evanston, Illinois 60201, USA)

Abstract

Schizophrenia risk: link to chromosome 6p22.1 A genome-wide association study using the Molecular Genetics of Schizophrenia case-control data set, followed by a meta-analysis that included over 8,000 cases and 19,000 controls, revealed that while common genetic variation that underlies risk to schizophrenia can be identified, there probably are few or no single common loci with large effects. The common variants identified here lie on chromosome 6p22.1 in a region that includes a histone gene cluster and several genes implicated in immunity.

Suggested Citation

  • Jianxin Shi & Douglas F. Levinson & Jubao Duan & Alan R. Sanders & Yonglan Zheng & Itsik Pe’er & Frank Dudbridge & Peter A. Holmans & Alice S. Whittemore & Bryan J. Mowry & Ann Olincy & Farooq Amin & , 2009. "Common variants on chromosome 6p22.1 are associated with schizophrenia," Nature, Nature, vol. 460(7256), pages 753-757, August.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7256:d:10.1038_nature08192
    DOI: 10.1038/nature08192
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    Cited by:

    1. Ming Li & Hui Zhang & Xiong-jian Luo & Lei Gao & Xue-bin Qi & Pierre-Antoine Gourraud & Bing Su, 2013. "Meta-Analysis Indicates That the European GWAS-Identified Risk SNP rs1344706 within ZNF804A Is Not Associated with Schizophrenia in Han Chinese Population," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-8, June.
    2. Chun Xu & Nagesh Aragam & Xia Li & Erika Cynthia Villla & Liang Wang & David Briones & Leonora Petty & Yolanda Posada & Tania Bedard Arana & Grace Cruz & ChunXiang Mao & Cynthia Camarillo & Brenda Bin, 2013. "BCL9 and C9orf5 Are Associated with Negative Symptoms in Schizophrenia: Meta-Analysis of Two Genome-Wide Association Studies," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-8, January.
    3. Masahiro Banno & Takayoshi Koide & Branko Aleksic & Kazuo Yamada & Tsutomu Kikuchi & Kunihiro Kohmura & Yasunori Adachi & Naoko Kawano & Itaru Kushima & Masashi Ikeda & Toshiya Inada & Takeo Yoshikawa, 2011. "A Case Control Association Study and Cognitive Function Analysis of Neuropilin and Tolloid-Like 1 Gene and Schizophrenia in the Japanese Population," PLOS ONE, Public Library of Science, vol. 6(12), pages 1-6, December.
    4. Rachel A Myers & Ferran Casals & Julie Gauthier & Fadi F Hamdan & Jon Keebler & Adam R Boyko & Carlos D Bustamante & Amelie M Piton & Dan Spiegelman & Edouard Henrion & Martine Zilversmit & Julie Huss, 2011. "A Population Genetic Approach to Mapping Neurological Disorder Genes Using Deep Resequencing," PLOS Genetics, Public Library of Science, vol. 7(2), pages 1-10, February.
    5. Brady Tang & Tricia Thornton-Wells & Kathleen D Askland, 2011. "Comparative Linkage Meta-Analysis Reveals Regionally-Distinct, Disparate Genetic Architectures: Application to Bipolar Disorder and Schizophrenia," PLOS ONE, Public Library of Science, vol. 6(4), pages 1-13, April.
    6. Zhongming Zhao & Bradley T Webb & Peilin Jia & T Bernard Bigdeli & Brion S Maher & Edwin van den Oord & Sarah E Bergen & Richard L Amdur & Francis A O'Neill & Dermot Walsh & Dawn L Thiselton & Xiangni, 2013. "Association Study of 167 Candidate Genes for Schizophrenia Selected by a Multi-Domain Evidence-Based Prioritization Algorithm and Neurodevelopmental Hypothesis," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-8, July.
    7. Logan Dumitrescu & Cara L Carty & Kira Taylor & Fredrick R Schumacher & Lucia A Hindorff & José L Ambite & Garnet Anderson & Lyle G Best & Kristin Brown-Gentry & Petra Bůžková & Christopher S Carlson , 2011. "Genetic Determinants of Lipid Traits in Diverse Populations from the Population Architecture using Genomics and Epidemiology (PAGE) Study," PLOS Genetics, Public Library of Science, vol. 7(6), pages 1-15, June.
    8. Peilin Jia & Lily Wang & Ayman H Fanous & Carlos N Pato & Todd L Edwards & The International Schizophrenia Consortium & Zhongming Zhao, 2012. "Network-Assisted Investigation of Combined Causal Signals from Genome-Wide Association Studies in Schizophrenia," PLOS Computational Biology, Public Library of Science, vol. 8(7), pages 1-11, July.
    9. Jingchun Chen & Darlene H Brunzell & Kia Jackson & Andrew van der Vaart & Jennie Z Ma & Thomas J Payne & Richard Sherva & Lindsay A Farrer & Pablo Gejman & Douglas F Levinson & Peter Holmans & Steven , 2011. "ACSL6 Is Associated with the Number of Cigarettes Smoked and Its Expression Is Altered by Chronic Nicotine Exposure," PLOS ONE, Public Library of Science, vol. 6(12), pages 1-10, December.

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