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Adult satellite cells and embryonic muscle progenitors have distinct genetic requirements

Author

Listed:
  • Christoph Lepper

    (Carnegie Institution, 3520 San Martin Drive, Baltimore, Maryland 21218, USA
    Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA)

  • Simon J. Conway

    (Riley Heart Research Center, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA)

  • Chen-Ming Fan

    (Carnegie Institution, 3520 San Martin Drive, Baltimore, Maryland 21218, USA)

Abstract

Muscle stem cells: satellite states The myogenic determinant Pax7 is thought to play a critical role in adult muscle stem cells — also known as satellite cells — but a formal demonstration has been lacking in vivo. Lepper et al. report the unexpected finding that when Pax7 is inactivated in adult mice, mutant satellite cells are not compromised in muscle regeneration, can self-renew and reoccupy the satellite niche, and support further regenerative processes. Pax7 is required only up to the juvenile period when progenitor cells transition into quiescence. The discovery of an age-dependent change in the genetic requirement for muscle stem cells cautions against inferring adult stem cell biology from embryonic studies and has direct implications for the use of stem cells from hosts of different ages in transplantation-based therapy.

Suggested Citation

  • Christoph Lepper & Simon J. Conway & Chen-Ming Fan, 2009. "Adult satellite cells and embryonic muscle progenitors have distinct genetic requirements," Nature, Nature, vol. 460(7255), pages 627-631, July.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7255:d:10.1038_nature08209
    DOI: 10.1038/nature08209
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    Cited by:

    1. Suyang Zhang & Feng Yang & Yile Huang & Liangqiang He & Yuying Li & Yi Ching Esther Wan & Yingzhe Ding & Kui Ming Chan & Ting Xie & Hao Sun & Huating Wang, 2023. "ATF3 induction prevents precocious activation of skeletal muscle stem cell by regulating H2B expression," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    2. Justin G. Boyer & Jiuzhou Huo & Sarah Han & Julian R. Havens & Vikram Prasad & Brian L. Lin & David A. Kass & Taejeong Song & Sakthivel Sadayappan & Ramzi J. Khairallah & Christopher W. Ward & Jeffery, 2022. "Depletion of skeletal muscle satellite cells attenuates pathology in muscular dystrophy," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    3. Ting Zhang & Carsten Künne & Dong Ding & Stefan Günther & Xinyue Guo & Yonggang Zhou & Xuejun Yuan & Thomas Braun, 2022. "Replication collisions induced by de-repressed S-phase transcription are connected with malignant transformation of adult stem cells," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    4. Chengyi Sun & Casey O. Swoboda & Fabian Montecino Morales & Cristofer Calvo & Michael J. Petrany & Sreeja Parameswaran & Andrew VonHandorf & Matthew T. Weirauch & Christoph Lepper & Douglas P. Millay, 2024. "Lineage tracing of nuclei in skeletal myofibers uncovers distinct transcripts and interplay between myonuclear populations," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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