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Presenilins are essential for regulating neurotransmitter release

Author

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  • Chen Zhang

    (Center for Neurologic Diseases, Brigham & Women’s Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
    Howard Hughes Medical Institute, Stanford University School of Medicine, Palo Alto, California 94304, USA)

  • Bei Wu

    (Center for Neurologic Diseases, Brigham & Women’s Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Vassilios Beglopoulos

    (Center for Neurologic Diseases, Brigham & Women’s Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Mary Wines-Samuelson

    (Center for Neurologic Diseases, Brigham & Women’s Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Dawei Zhang

    (Center for Neurologic Diseases, Brigham & Women’s Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Ioannis Dragatsis

    (The University of Tennessee, Health Science Center, Memphis, Tennessee 38163, USA)

  • Thomas C. Südhof

    (Howard Hughes Medical Institute, Stanford University School of Medicine, Palo Alto, California 94304, USA)

  • Jie Shen

    (Center for Neurologic Diseases, Brigham & Women’s Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA)

Abstract

Presenilin action The presenilin genes have been genetically associated with familial cases of Alzheimer's disease but where they operate and what they do in neurons has been unclear. Zhang et al. demonstrate in mouse models that presinilins act in the presynaptic compartment to control activity-dependent neurotransmitter release, a process essential to neuronal computation, learning and memory. These findings suggest that presynaptic dysfunction might be an early cause of dementia in neurodegenerative disorders.

Suggested Citation

  • Chen Zhang & Bei Wu & Vassilios Beglopoulos & Mary Wines-Samuelson & Dawei Zhang & Ioannis Dragatsis & Thomas C. Südhof & Jie Shen, 2009. "Presenilins are essential for regulating neurotransmitter release," Nature, Nature, vol. 460(7255), pages 632-636, July.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7255:d:10.1038_nature08177
    DOI: 10.1038/nature08177
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    Cited by:

    1. Anika Perdok & Zoë P. Van Acker & Céline Vrancx & Ragna Sannerud & Inge Vorsters & Assunta Verrengia & Zsuzsanna Callaerts-Végh & Eline Creemers & Sara Gutiérrez Fernández & Britt D’hauw & Lutgarde Se, 2024. "Altered expression of Presenilin2 impacts endolysosomal homeostasis and synapse function in Alzheimer’s disease-relevant brain circuits," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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