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Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation

Author

Listed:
  • Sundeep Kalantry

    (Department of Genetics,
    Carolina Center for Genome Sciences,
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599-7264, USA)

  • Sonya Purushothaman

    (Department of Genetics,
    Carolina Center for Genome Sciences,
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599-7264, USA)

  • Randall Bryant Bowen

    (Department of Genetics,
    Carolina Center for Genome Sciences,
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599-7264, USA)

  • Joshua Starmer

    (Department of Genetics,
    Carolina Center for Genome Sciences,
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599-7264, USA)

  • Terry Magnuson

    (Department of Genetics,
    Carolina Center for Genome Sciences,
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599-7264, USA)

Abstract

X-chromosome inactivation Female mammals carry two copies of the X chromosome, compared to the one X and one Y of the male, and to counter the potentially toxic effect of a double-dose of a gene, most of the genes on one X chromosome are silenced. This process of X-chromosome inactivation (XCI) has long been assumed to be triggered by the expression of the RNA gene Xist, specifically the copy on the inactive X chromosome. New work on embryos of mice engineered to contain a defective Xist gene on their future inactive X chromosome reveals a more complicated picture. In fact, silencing of the paternal X chromosome during imprinted XCI can be initiated in the absence of paternal Xist. In the continued absence of Xist the X chromosome eventually reactivates, suggesting that its role may be to stabilize silencing over the long term.

Suggested Citation

  • Sundeep Kalantry & Sonya Purushothaman & Randall Bryant Bowen & Joshua Starmer & Terry Magnuson, 2009. "Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation," Nature, Nature, vol. 460(7255), pages 647-651, July.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7255:d:10.1038_nature08161
    DOI: 10.1038/nature08161
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    Cited by:

    1. Milan Kumar Samanta & Srimonta Gayen & Clair Harris & Emily Maclary & Yumie Murata-Nakamura & Rebecca M. Malcore & Robert S. Porter & Patricia M. Garay & Christina N. Vallianatos & Paul B. Samollow & , 2022. "Activation of Xist by an evolutionarily conserved function of KDM5C demethylase," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Marissa Cloutier & Surinder Kumar & Emily Buttigieg & Laura Keller & Brandon Lee & Aaron Williams & Sandra Mojica-Perez & Indri Erliandri & Andre Monteiro Da Rocha & Kenneth Cadigan & Gary D. Smith & , 2022. "Preventing erosion of X-chromosome inactivation in human embryonic stem cells," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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