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MicroRNA-mediated switching of chromatin-remodelling complexes in neural development

Author

Listed:
  • Andrew S. Yoo

    (Howard Hughes Medical Institute,
    Department of Developmental Biology,
    Stanford University, Stanford, California 94305, USA)

  • Brett T. Staahl

    (Howard Hughes Medical Institute,
    Department of Developmental Biology,)

  • Lei Chen

    (Howard Hughes Medical Institute,
    Department of Developmental Biology,
    Stanford University, Stanford, California 94305, USA)

  • Gerald R. Crabtree

    (Howard Hughes Medical Institute,
    Department of Developmental Biology,
    Stanford University, Stanford, California 94305, USA)

Abstract

MicroRNA mediates key step in neurodevelopment A key step in the development of the vertebrate nervous system occurs when cells exit the multipotent neural stem cell state and enter a phase of post-mitotic neural development. This involves a switch in subunit composition of the SWI/SNF-like BAF chromatin remodelling complexes. Here, Yoo et al. show that the switch in BAF subunits is mediated by two microRNAs that are selectively expressed in post-mitotic neurons.

Suggested Citation

  • Andrew S. Yoo & Brett T. Staahl & Lei Chen & Gerald R. Crabtree, 2009. "MicroRNA-mediated switching of chromatin-remodelling complexes in neural development," Nature, Nature, vol. 460(7255), pages 642-646, July.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7255:d:10.1038_nature08139
    DOI: 10.1038/nature08139
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    Cited by:

    1. Ariane Lismer & Sarah Kimmins, 2023. "Emerging evidence that the mammalian sperm epigenome serves as a template for embryo development," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    2. Dominik Laubscher & Berkley E. Gryder & Benjamin D. Sunkel & Thorkell Andresson & Marco Wachtel & Sudipto Das & Bernd Roschitzki & Witold Wolski & Xiaoli S. Wu & Hsien-Chao Chou & Young K. Song & Chao, 2021. "BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma," Nature Communications, Nature, vol. 12(1), pages 1-16, December.

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