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The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis

Author

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  • Yiguo Wang

    (Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Liliana Vera

    (Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Wolfgang H. Fischer

    (Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Marc Montminy

    (Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

Abstract

Fast reaction of a CREB coactivator In fasted mammals, circulating pancreatic glucagon stimulates gluconeogenesis in the liver in part through the CREB coactivator CRTC2/TORC2. CRTC2 is now shown to function as a dual sensor for fasting signals and endoplasmic reticulum (ER) stress in the liver. Crosstalk between fasting and ER stress pathways at the level of this transcriptional coactivator contributes to glucose homeostasis under lean conditions and to the development of hyperglycaemia in obesity.

Suggested Citation

  • Yiguo Wang & Liliana Vera & Wolfgang H. Fischer & Marc Montminy, 2009. "The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis," Nature, Nature, vol. 460(7254), pages 534-537, July.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7254:d:10.1038_nature08111
    DOI: 10.1038/nature08111
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    Cited by:

    1. An Pan & Xiao-Meng Sun & Feng-Qing Huang & Jin-Feng Liu & Yuan-Yuan Cai & Xin Wu & Raphael N. Alolga & Ping Li & Bao-Lin Liu & Qun Liu & Lian-Wen Qi, 2022. "The mitochondrial β-oxidation enzyme HADHA restrains hepatic glucagon response by promoting β-hydroxybutyrate production," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Éverton Lopes Vogt & Maiza Cristina Von Dentz & Débora Santos Rocha & Jorge Felipe Argenta Model & Lucas Stahlhöfer Kowalewski & Samir Khal de Souza & Vitória de Oliveira Girelli & Paulo Ivo Homem de , 2021. "Metabolic and Molecular Subacute Effects of a Single Moderate-Intensity Exercise Bout, Performed in the Fasted State, in Obese Male Rats," IJERPH, MDPI, vol. 18(14), pages 1-17, July.

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