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Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus

Author

Listed:
  • Suzana Hadjur

    (Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK)

  • Luke M. Williams

    (Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK)

  • Natalie K. Ryan

    (Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK)

  • Bradley S. Cobb

    (Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK)

  • Tom Sexton

    (Laboratory of Chromatin and Gene Expression, The Babraham Institute)

  • Peter Fraser

    (Laboratory of Chromatin and Gene Expression, The Babraham Institute)

  • Amanda G. Fisher

    (Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK)

  • Matthias Merkenschlager

    (Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK)

Abstract

Cohesin branches out As well as its role in sister chromatid cohesion, the cohesin protein complex is thought be involved in the control of gene expression. Hadjur et al. show here that cohesin is involved topologically and mechanistically in long-range interactions at the cytokine locus IFNG.

Suggested Citation

  • Suzana Hadjur & Luke M. Williams & Natalie K. Ryan & Bradley S. Cobb & Tom Sexton & Peter Fraser & Amanda G. Fisher & Matthias Merkenschlager, 2009. "Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus," Nature, Nature, vol. 460(7253), pages 410-413, July.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7253:d:10.1038_nature08079
    DOI: 10.1038/nature08079
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    Cited by:

    1. Georgii Pobegalov & Lee-Ya Chu & Jan-Michael Peters & Maxim I. Molodtsov, 2023. "Single cohesin molecules generate force by two distinct mechanisms," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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