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The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting

Author

Listed:
  • Mary E. Donohoe

    (Howard Hughes Medical Institute,
    Massachusetts General Hospital
    Harvard Medical School
    Present address: Burke Medical Research Institute, Weill Cornell Medical College, White Plains, New York 10605, USA.)

  • Susana S. Silva

    (Howard Hughes Medical Institute,
    Massachusetts General Hospital
    Harvard Medical School)

  • Stefan F. Pinter

    (Howard Hughes Medical Institute,
    Massachusetts General Hospital
    Harvard Medical School)

  • Na Xu

    (Howard Hughes Medical Institute,
    Massachusetts General Hospital
    Harvard Medical School)

  • Jeannie T. Lee

    (Howard Hughes Medical Institute,
    Massachusetts General Hospital
    Harvard Medical School
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA)

Abstract

Pluripotency and the X chromosome During both stem cell differentiation and X chromosome inactivation, the process that silences one female X chromosome to ensure gene dosage parity between the sexes, chromatin undergoes epigenetic reprogramming to lock in a new state. Reprogramming of differentiated cells into iPS cells also causes reactivation of the inactivated X chromosome, and it has been proposed that the pluripotency factor Oct4 links both processes. In this study, Donohoe et al. find that Oct4 regulates X-chromosome inactivation by triggering X-chromosome pairing and counting. Oct4 interacts with both noncoding RNA genes (Tsix and Xite) and proteins (Ctcf and Yy1). This work shows that there is a complex network involved in epigenetic reprogramming of the X chromosome in stem cells.

Suggested Citation

  • Mary E. Donohoe & Susana S. Silva & Stefan F. Pinter & Na Xu & Jeannie T. Lee, 2009. "The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting," Nature, Nature, vol. 460(7251), pages 128-132, July.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7251:d:10.1038_nature08098
    DOI: 10.1038/nature08098
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    Cited by:

    1. Teresa Robert-Finestra & Beatrice F. Tan & Hegias Mira-Bontenbal & Erika Timmers & Cristina Gontan & Sarra Merzouk & Benedetto Daniele Giaimo & François Dossin & Wilfred F. J. IJcken & John W. M. Mart, 2021. "SPEN is required for Xist upregulation during initiation of X chromosome inactivation," Nature Communications, Nature, vol. 12(1), pages 1-13, December.

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