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Enhancing CD8 T-cell memory by modulating fatty acid metabolism

Author

Listed:
  • Erika L. Pearce

    (Department of Pathology and Laboratory Medicine,)

  • Matthew C. Walsh

    (Department of Pathology and Laboratory Medicine,)

  • Pedro J. Cejas

    (Department of Pathology and Laboratory Medicine,)

  • Gretchen M. Harms

    (Department of Pathology and Laboratory Medicine,)

  • Hao Shen

    (Department of Microbiology,)

  • Li-San Wang

    (Department of Pathology and Laboratory Medicine,
    Penn Center for Bioinformatics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA)

  • Russell G. Jones

    (McGill Cancer Centre, McGill University, Montreal, QC, H3G 1Y6, Canada)

  • Yongwon Choi

    (Department of Pathology and Laboratory Medicine,)

Abstract

T-cell memory linked to energy metabolism CD8 T cells play a crucial role in immunity to infection and cancer. The predictable pattern of a CD8 T-cell response to infection is well established, but the underlying cellular mechanisms regulating the transition to memory remain undefined. Here, Pearce et al. show that metabolic conversion to catabolic pathways of energy generation is key to CD8 T-cell memory development in vivo. CD8 T cells switch from glucose metabolism to fatty acid metabolism as they differentiate into a 'memory' cell that can 'remember' past infections. The process is regulated by the tumour necrosis factor receptor-associated factor protein TRAF6.

Suggested Citation

  • Erika L. Pearce & Matthew C. Walsh & Pedro J. Cejas & Gretchen M. Harms & Hao Shen & Li-San Wang & Russell G. Jones & Yongwon Choi, 2009. "Enhancing CD8 T-cell memory by modulating fatty acid metabolism," Nature, Nature, vol. 460(7251), pages 103-107, July.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7251:d:10.1038_nature08097
    DOI: 10.1038/nature08097
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    Cited by:

    1. Justin A. Guerrero & Dorota D. Klysz & Yiyun Chen & Meena Malipatlolla & Jameel Lone & Carley Fowler & Lucille Stuani & Audre May & Malek Bashti & Peng Xu & Jing Huang & Basil Michael & Kévin Contrepo, 2024. "GLUT1 overexpression in CAR-T cells induces metabolic reprogramming and enhances potency," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    2. Meng-Han Wu & Felipe Valenca-Pereira & Francesca Cendali & Emily L. Giddings & Catherine Pham-Danis & Michael C. Yarnell & Amanda J. Novak & Tonya M. Brunetti & Scott B. Thompson & Jorge Henao-Mejia &, 2024. "Deleting the mitochondrial respiration negative regulator MCJ enhances the efficacy of CD8+ T cell adoptive therapies in pre-clinical studies," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
    3. Matteo Villa & David E. Sanin & Petya Apostolova & Mauro Corrado & Agnieszka M. Kabat & Carmine Cristinzio & Annamaria Regina & Gustavo E. Carrizo & Nisha Rana & Michal A. Stanczak & Francesc Baixauli, 2024. "Prostaglandin E2 controls the metabolic adaptation of T cells to the intestinal microenvironment," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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