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Biomechanical forces promote embryonic haematopoiesis

Author

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  • Luigi Adamo

    (Center for Excellence in Vascular Biology, Boston, Massachusetts 02115, USA)

  • Olaia Naveiras

    (Stem Cell Transplantation Program, Brigham and Women’s Hospital; Harvard Stem Cell Institute; Manton Center for Orphan Disease Research; Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School)

  • Pamela L. Wenzel

    (Stem Cell Transplantation Program, Brigham and Women’s Hospital; Harvard Stem Cell Institute; Manton Center for Orphan Disease Research; Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School)

  • Shannon McKinney-Freeman

    (Stem Cell Transplantation Program, Brigham and Women’s Hospital; Harvard Stem Cell Institute; Manton Center for Orphan Disease Research; Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School)

  • Peter J. Mack

    (Center for Excellence in Vascular Biology, Boston, Massachusetts 02115, USA)

  • Jorge Gracia-Sancho

    (Center for Excellence in Vascular Biology, Boston, Massachusetts 02115, USA)

  • Astrid Suchy-Dicey

    (Center for Excellence in Vascular Biology, Boston, Massachusetts 02115, USA)

  • Momoko Yoshimoto

    (Indiana University School of Medicine, Indianapolis, Indiana 46202, USA)

  • M. William Lensch

    (Stem Cell Transplantation Program, Brigham and Women’s Hospital; Harvard Stem Cell Institute; Manton Center for Orphan Disease Research; Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School)

  • Mervin C. Yoder

    (Indiana University School of Medicine, Indianapolis, Indiana 46202, USA)

  • Guillermo García-Cardeña

    (Center for Excellence in Vascular Biology, Boston, Massachusetts 02115, USA)

  • George Q. Daley

    (Stem Cell Transplantation Program, Brigham and Women’s Hospital; Harvard Stem Cell Institute; Manton Center for Orphan Disease Research; Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School)

Abstract

Blood cells by heartbeat Following initiation of the heartbeat in vertebrate embryos, cells lining the aorta, the placental vessels and the umbilical and vitelline arteries begin to form haematopoietic cells. It has been suggested that biomechanical forces imposed on the vascular wall by the heartbeat, which sets up vascular flow and wall shear stress, could be the cue for the production of these early blood cells. Working with mouse embryonic stem cells differentiated in vitro and in mouse embryos, Adamo et al. show that exposure to fluid shear stress increases haematopoietic colony-forming potential and expression of haematopoietic markers both in vitro and in vivo. The confirmation of a link between the initiation of vascular flow and embryonic blood cell development provides new pointers for research on the production of haematopoietic progenitors for possible use in stem-cell-based therapies.

Suggested Citation

  • Luigi Adamo & Olaia Naveiras & Pamela L. Wenzel & Shannon McKinney-Freeman & Peter J. Mack & Jorge Gracia-Sancho & Astrid Suchy-Dicey & Momoko Yoshimoto & M. William Lensch & Mervin C. Yoder & Guiller, 2009. "Biomechanical forces promote embryonic haematopoiesis," Nature, Nature, vol. 459(7250), pages 1131-1135, June.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7250:d:10.1038_nature08073
    DOI: 10.1038/nature08073
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    Cited by:

    1. Wen Hao Neo & Yiran Meng & Alba Rodriguez-Meira & Muhammad Z. H. Fadlullah & Christopher A. G. Booth & Emanuele Azzoni & Supat Thongjuea & Marella F. T. R. Bruijn & Sten Eirik W. Jacobsen & Adam J. Me, 2021. "Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    2. Dorothee Bornhorst & Amulya V. Hejjaji & Lena Steuter & Nicole M. Woodhead & Paul Maier & Alessandra Gentile & Alice Alhajkadour & Octavia Santis Larrain & Michael Weber & Khrievono Kikhi & Stefan Gue, 2024. "The heart is a resident tissue for hematopoietic stem and progenitor cells in zebrafish," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    3. Aleksandr Vasilyev & Yan Liu & Nathan Hellman & Narendra Pathak & Iain A Drummond, 2012. "Mechanical Stretch and PI3K Signaling Link Cell Migration and Proliferation to Coordinate Epithelial Tubule Morphogenesis in the Zebrafish Pronephros," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-11, July.

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