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Subcellular homeostasis of phytohormone auxin is mediated by the ER-localized PIN5 transporter

Author

Listed:
  • Jozef Mravec

    (Ghent University
    Center for Plant Molecular Biology (ZMBP), University Tübingen)

  • Petr Skůpa

    (Institute of Experimental Botany, ASCR, 165 02 Praha 6, Czech Republic)

  • Aurélien Bailly

    (Zürich-Basel Plant Science Center, University of Zurich, Institute of Plant Biology, Molecular Plant Physiology)

  • Klára Hoyerová

    (Institute of Experimental Botany, ASCR, 165 02 Praha 6, Czech Republic)

  • Pavel Křeček

    (Institute of Experimental Botany, ASCR, 165 02 Praha 6, Czech Republic)

  • Agnieszka Bielach

    (Ghent University)

  • Jan Petrášek

    (Institute of Experimental Botany, ASCR, 165 02 Praha 6, Czech Republic
    Faculty of Science, Charles University)

  • Jing Zhang

    (Ghent University
    Center for Plant Molecular Biology (ZMBP), University Tübingen)

  • Vassilena Gaykova

    (Center for Plant Molecular Biology (ZMBP), University Tübingen)

  • York-Dieter Stierhof

    (Center for Plant Molecular Biology (ZMBP), University Tübingen)

  • Petre I. Dobrev

    (Institute of Experimental Botany, ASCR, 165 02 Praha 6, Czech Republic)

  • Kateřina Schwarzerová

    (Faculty of Science, Charles University)

  • Jakub Rolčík

    (Laboratory of Growth Regulators of the Institute of Experimental Botany, ASCR and Faculty of Science, Palacký University)

  • Daniela Seifertová

    (Institute of Experimental Botany, ASCR, 165 02 Praha 6, Czech Republic)

  • Christian Luschnig

    (University of Natural Resources and Applied Life Sciences - BOKU)

  • Eva Benková

    (Ghent University)

  • Eva Zažímalová

    (Institute of Experimental Botany, ASCR, 165 02 Praha 6, Czech Republic)

  • Markus Geisler

    (Zürich-Basel Plant Science Center, University of Zurich, Institute of Plant Biology, Molecular Plant Physiology)

  • Jiří Friml

    (Ghent University
    Faculty of Science, Masaryk University)

Abstract

Auxin and subcellular compartmentalization The plant hormone auxin is a key regulator of growth and development. The PINFORMED (PIN) efflux carriers are asymmetrically localized on the plasma membrane and mediate directional auxin transport between cells. In this study, Mravec et al. characterize an atypical member of the PIN family, PIN5, in Arabidopsis thaliana. They find that while it encodes a functional auxin transporter and is required for developmental processes, it does not mediate intercellular transport of auxin. Instead it is localized to the endoplasmic reticulum (ER) where it is presumed to mediate auxin flow from the cytosol to the lumen of the ER, thus regulating intracellular levels of the hormone. Sequence analysis and mutagenesis studies between plasma membrane and ER-localized PIN proteins suggest that only small motif changes were involved during diversification of these two protein classes. These results reveal a previously unsuspected way of regulating cellular homeostasis of signalling compounds by their subcellular compartmentalization.

Suggested Citation

  • Jozef Mravec & Petr Skůpa & Aurélien Bailly & Klára Hoyerová & Pavel Křeček & Agnieszka Bielach & Jan Petrášek & Jing Zhang & Vassilena Gaykova & York-Dieter Stierhof & Petre I. Dobrev & Kateřina Schw, 2009. "Subcellular homeostasis of phytohormone auxin is mediated by the ER-localized PIN5 transporter," Nature, Nature, vol. 459(7250), pages 1136-1140, June.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7250:d:10.1038_nature08066
    DOI: 10.1038/nature08066
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    Cited by:

    1. Huaiguo Shang & Na Zhang & Zhouli Xie & Siyu Deng & Licong Yi & Xing Huang, 2021. "Genome-Wide Identification and Expression of the PIN Auxin Efflux Carrier Gene Family in Watermelon ( Citrullus lanatus )," Agriculture, MDPI, vol. 11(5), pages 1-11, May.
    2. Tao Zhou & Jiajia Chen & Yanhui Huang & Zhengyu Jin & Jianrong Li & Yan Li & Xiaofang Zeng, 2022. "Genome-Wide Identification and Expression Analysis of the PIN Auxin Transporter Gene Family in Zanthoxylum armatum DC," Agriculture, MDPI, vol. 12(9), pages 1-16, August.

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