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A spatial gradient coordinates cell size and mitotic entry in fission yeast

Author

Listed:
  • James B. Moseley

    (The Rockefeller University, New York, New York 10065, USA)

  • Adeline Mayeux

    (Institut Curie, Centre de Recherche and CNRS UMR144)

  • Anne Paoletti

    (Institut Curie, Centre de Recherche and CNRS UMR144)

  • Paul Nurse

    (The Rockefeller University, New York, New York 10065, USA)

Abstract

A time to divide Proliferating cells divide when they reach a certain size owing to regulated activity of cyclin-dependent kinase (Cdk1), but the links between Cdk1 regulators and mechanisms monitoring cell size have been elusive. Two papers in this issue describe how a fission yeast kinase Pom1, known to be a determinant of cell polarity, forms a polar gradient within the cell, which measures the length of the rod-shaped cells and induces cell division via negative regulation of the Cdk1 inhibitor Wee1.

Suggested Citation

  • James B. Moseley & Adeline Mayeux & Anne Paoletti & Paul Nurse, 2009. "A spatial gradient coordinates cell size and mitotic entry in fission yeast," Nature, Nature, vol. 459(7248), pages 857-860, June.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7248:d:10.1038_nature08074
    DOI: 10.1038/nature08074
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    Cited by:

    1. Gu, Xinyue & Chen, Pengyu & Fan, Chao, 2024. "Socio-demographic inequalities in the impacts of extreme temperatures on population mobility11This research received no specific grant from any funding agency, commercial or not-for-profit sectors," Journal of Transport Geography, Elsevier, vol. 114(C).
    2. Rashidi, Armin & Shelton, Deborah E. & Michod, Richard E., 2015. "A Darwinian approach to the origin of life cycles with group properties," Theoretical Population Biology, Elsevier, vol. 102(C), pages 76-84.

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