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Polar gradients of the DYRK-family kinase Pom1 couple cell length with the cell cycle

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  • Sophie G. Martin

    (Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Génopode Building, 1015 Lausanne, Switzerland)

  • Martine Berthelot-Grosjean

    (Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Génopode Building, 1015 Lausanne, Switzerland)

Abstract

A time to divide Proliferating cells divide when they reach a certain size owing to regulated activity of cyclin-dependent kinase (Cdk1), but the links between Cdk1 regulators and mechanisms monitoring cell size have been elusive. Two papers in this issue describe how a fission yeast kinase Pom1, known to be a determinant of cell polarity, forms a polar gradient within the cell, which measures the length of the rod-shaped cells and induces cell division via negative regulation of the Cdk1 inhibitor Wee1.

Suggested Citation

  • Sophie G. Martin & Martine Berthelot-Grosjean, 2009. "Polar gradients of the DYRK-family kinase Pom1 couple cell length with the cell cycle," Nature, Nature, vol. 459(7248), pages 852-856, June.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7248:d:10.1038_nature08054
    DOI: 10.1038/nature08054
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    Cited by:

    1. Rashidi, Armin & Shelton, Deborah E. & Michod, Richard E., 2015. "A Darwinian approach to the origin of life cycles with group properties," Theoretical Population Biology, Elsevier, vol. 102(C), pages 76-84.

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