IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v459y2009i7247d10.1038_nature08039.html
   My bibliography  Save this article

Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors

Author

Listed:
  • Jun K. Takeuchi

    (Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
    Global-Edge Institute, Tokyo Institute of Technology, Frontier S2-16, Nagatsuda, Midori-ku, Yokohama, Kanagawa 226-8503, Japan)

  • Benoit G. Bruneau

    (Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
    Cardiovascular Research Institute, and Institute for Regeneration Medicine, University of California, San Francisco, California 94158, USA)

Abstract

Heart-cell generation The heart has little regenerative capacity after damage, so understanding the factors required to produce new cardiac myocytes is of great interest. Jun Takeuchi and Benoit Bruneau have investigated the minimal requirements for transdifferentiation of mouse mesoderm to cardiac myocytes, and find that two cardiac transcription factors and a cardiac-specific subunit of BAF chromatin-remodelling complexes are sufficient to direct differentiation of mouse mesoderm into beating cardiomyocytes. Addition of a further transcription factor promotes differentiation into contracting cardiomyocytes, and repression of noncardiac mesodermal genes. Defining the requirements for cardiac cellular differentiation may help in the long-term goal of regenerating cardiomyocytes for therapies.

Suggested Citation

  • Jun K. Takeuchi & Benoit G. Bruneau, 2009. "Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors," Nature, Nature, vol. 459(7247), pages 708-711, June.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7247:d:10.1038_nature08039
    DOI: 10.1038/nature08039
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature08039
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature08039?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yinuo Wang & Adel Elsherbiny & Linda Kessler & Julio Cordero & Haojie Shi & Heike Serke & Olga Lityagina & Felix A. Trogisch & Mona Malek Mohammadi & Ibrahim El-Battrawy & Johannes Backs & Thomas Wiel, 2022. "Lamin A/C-dependent chromatin architecture safeguards naïve pluripotency to prevent aberrant cardiovascular cell fate and function," Nature Communications, Nature, vol. 13(1), pages 1-24, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:459:y:2009:i:7247:d:10.1038_nature08039. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.