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F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage

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  • Manas K. Santra

    (Howard Hughes Medical Institute, Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA)

  • Narendra Wajapeyee

    (Howard Hughes Medical Institute, Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA)

  • Michael R. Green

    (Howard Hughes Medical Institute, Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA)

Abstract

DNA damage role of FBXO31 in cell growth arrest During the cellular response to DNA damage in eukaryotes, cell-cycle arrest is coordinated with DNA repair. Here the human F-box protein FBXO31 is shown to regulate the cell-cycle transition from G1 to S phase in response to DNA damage by mediating degradation of cyclin D1. Diverse DNA damaging agents result in increased FBXO31 levels, indicating that FBXO31 is a general mediator required to arrest cell growth after DNA damage.

Suggested Citation

  • Manas K. Santra & Narendra Wajapeyee & Michael R. Green, 2009. "F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage," Nature, Nature, vol. 459(7247), pages 722-725, June.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7247:d:10.1038_nature08011
    DOI: 10.1038/nature08011
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    Cited by:

    1. Ji Min Lee & Henrik M. Hammarén & Mikhail M. Savitski & Sung Hee Baek, 2023. "Control of protein stability by post-translational modifications," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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