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Frequent inactivation of A20 in B-cell lymphomas

Author

Listed:
  • Motohiro Kato

    (Cancer Genomics Project
    Pediatrics,)

  • Masashi Sanada

    (Cancer Genomics Project
    Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, 4-1-8, Honcho, Kawaguchi-shi, Saitama 332-0012, Japan)

  • Itaru Kato

    (Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan)

  • Yasuharu Sato

    (Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan)

  • Junko Takita

    (Cancer Genomics Project
    Pediatrics,
    Cell Therapy and Transplantation Medicine, and,)

  • Kengo Takeuchi

    (The Cancer Institute of Japanese Foundation for Cancer Research, Japan, 3-10-6 Ariake, Koto-ku, Tokyo 135-8550, Japan)

  • Akira Niwa

    (Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan)

  • Yuyan Chen

    (Cancer Genomics Project
    Pediatrics,)

  • Kumi Nakazaki

    (Cancer Genomics Project
    Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, 4-1-8, Honcho, Kawaguchi-shi, Saitama 332-0012, Japan)

  • Junko Nomoto

    (Hospital, and)

  • Yoshitaka Asakura

    (Hospital, and)

  • Satsuki Muto

    (Cancer Genomics Project)

  • Azusa Tamura

    (Cancer Genomics Project)

  • Mitsuru Iio

    (Cancer Genomics Project)

  • Yoshiki Akatsuka

    (Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan)

  • Yasuhide Hayashi

    (Gunma Children’s Medical Center, 779 Shimohakoda, Hokkitsu-machi, Shibukawa 377-8577, Japan)

  • Hiraku Mori

    (Internal Medicine, Showa University Fujigaoka Hospital, 1-30, Fujigaoka, Aoba-ku, Yokohama-shi, Kanagawa 227-8501, Japan)

  • Takashi Igarashi

    (Pediatrics,)

  • Mineo Kurokawa

    (Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan)

  • Shigeru Chiba

    (Cell Therapy and Transplantation Medicine, and,)

  • Shigeo Mori

    (Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan)

  • Yuichi Ishikawa

    (The Cancer Institute of Japanese Foundation for Cancer Research, Japan, 3-10-6 Ariake, Koto-ku, Tokyo 135-8550, Japan)

  • Koji Okamoto

    (Early Oncogenesis Research Project, Research Institute, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan)

  • Kensei Tobinai

    (Hospital, and)

  • Hitoshi Nakagama

    (Early Oncogenesis Research Project, Research Institute, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan)

  • Tatsutoshi Nakahata

    (Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan)

  • Tadashi Yoshino

    (Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan)

  • Yukio Kobayashi

    (Hospital, and)

  • Seishi Ogawa

    (Cancer Genomics Project
    Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, 4-1-8, Honcho, Kawaguchi-shi, Saitama 332-0012, Japan)

Abstract

A20 link to B-cell lymphoma Two groups report in this issue that A20 protein, a negative regulator of NF-κB signalling pathways, is frequently inactivated in patients with B-cell lymphoma. Kato et al. show that cells lacking the A20 gene generate tumours in immunodeficient mice, and that tumour formation is suppressed when the protein is re-expressed. Compagno et al. show that A20 is inactivated in around 30% of patients with B-cell lymphoma. Both groups show that A20 protein suppresses cell growth in vitro and prompts cells to commit suicide.

Suggested Citation

  • Motohiro Kato & Masashi Sanada & Itaru Kato & Yasuharu Sato & Junko Takita & Kengo Takeuchi & Akira Niwa & Yuyan Chen & Kumi Nakazaki & Junko Nomoto & Yoshitaka Asakura & Satsuki Muto & Azusa Tamura &, 2009. "Frequent inactivation of A20 in B-cell lymphomas," Nature, Nature, vol. 459(7247), pages 712-716, June.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7247:d:10.1038_nature07969
    DOI: 10.1038/nature07969
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    Cited by:

    1. Ashley E. Culver-Cochran & Aishlin Hassan & Kathleen Hueneman & Kwangmin Choi & Averil Ma & Brett VanCauwenbergh & Eric O’Brien & Mark Wunderlich & John P. Perentesis & Daniel T. Starczynowski, 2024. "Chemotherapy resistance in acute myeloid leukemia is mediated by A20 suppression of spontaneous necroptosis," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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