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Metamorphic enzyme assembly in polyketide diversification

Author

Listed:
  • Liangcai Gu

    (Life Sciences Institute,
    Department of Medicinal Chemistry,)

  • Bo Wang

    (Department of Chemistry,)

  • Amol Kulkarni

    (University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA)

  • Todd W. Geders

    (Life Sciences Institute,)

  • Rashel V. Grindberg

    (Scripps Institution of Oceanography & Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, California 92093, USA)

  • Lena Gerwick

    (Scripps Institution of Oceanography & Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, California 92093, USA)

  • Kristina Håkansson

    (Department of Chemistry,)

  • Peter Wipf

    (University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA)

  • Janet L. Smith

    (Life Sciences Institute,
    Department of Biological Chemistry,)

  • William H. Gerwick

    (Scripps Institution of Oceanography & Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, California 92093, USA)

  • David H. Sherman

    (Life Sciences Institute,
    Department of Medicinal Chemistry,
    Department of Chemistry,
    University of Michigan, Ann Arbor, Michigan 48109, USA)

Abstract

Cyclopropane and vinyl chloride share biosynthesis resources A study of the pathways responsible for the synthesis of two natural products — curacin and jamaicamide — in the cyanobacterium Lyngbya majuscula reveals two biosynthetic pathways with high sequence identity. Yet they are responsible for the production of two dramatically different chemical motifs: a β-branched cyclopropane in the curacin A pathway, and a vinyl chloride group in the jamaicamide pathway. The biochemical characterization of several domains of the biosynthetic pathways, including the halogenase domains and the enoyl reductase domains, reveals details of the mechanisms by which the cyclopropane and vinyl chloride groups are generated.

Suggested Citation

  • Liangcai Gu & Bo Wang & Amol Kulkarni & Todd W. Geders & Rashel V. Grindberg & Lena Gerwick & Kristina Håkansson & Peter Wipf & Janet L. Smith & William H. Gerwick & David H. Sherman, 2009. "Metamorphic enzyme assembly in polyketide diversification," Nature, Nature, vol. 459(7247), pages 731-735, June.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7247:d:10.1038_nature07870
    DOI: 10.1038/nature07870
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    Cited by:

    1. Sabrina Collin & Russell J. Cox & Cédric Paris & Christophe Jacob & Benjamin Chagot & Kira J. Weissman & Arnaud Gruez, 2023. "Decrypting the programming of β-methylation in virginiamycin M biosynthesis," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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