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NAADP mobilizes calcium from acidic organelles through two-pore channels

Author

Listed:
  • Peter J. Calcraft

    (Centre for Integrative Physiology, College of Medicine and Veterinary Medicine, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9XD, Scotland, UK)

  • Margarida Ruas

    (University of Oxford, Mansfield Road, Oxford OX1 3QT, UK)

  • Zui Pan

    (UMDNJ-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, USA)

  • Xiaotong Cheng

    (University of Oxford, Mansfield Road, Oxford OX1 3QT, UK)

  • Abdelilah Arredouani

    (University of Oxford, Mansfield Road, Oxford OX1 3QT, UK)

  • Xuemei Hao

    (College of Life Sciences, Peking University
    Biochemistry, and Center for Molecular Neurobiology, The Ohio State University, 1060 Carmack Road, Columbus, Ohio 43210, USA)

  • Jisen Tang

    (Biochemistry, and Center for Molecular Neurobiology, The Ohio State University, 1060 Carmack Road, Columbus, Ohio 43210, USA)

  • Katja Rietdorf

    (University of Oxford, Mansfield Road, Oxford OX1 3QT, UK)

  • Lydia Teboul

    (The Mary Lyon Centre, MRC Harwell, Oxfordshire OX11 0RD, UK)

  • Kai-Ting Chuang

    (University of Oxford, Mansfield Road, Oxford OX1 3QT, UK)

  • Peihui Lin

    (UMDNJ-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, USA)

  • Rui Xiao

    (Biochemistry, and Center for Molecular Neurobiology, The Ohio State University, 1060 Carmack Road, Columbus, Ohio 43210, USA)

  • Chunbo Wang

    (Biochemistry, and Center for Molecular Neurobiology, The Ohio State University, 1060 Carmack Road, Columbus, Ohio 43210, USA)

  • Yingmin Zhu

    (Biochemistry, and Center for Molecular Neurobiology, The Ohio State University, 1060 Carmack Road, Columbus, Ohio 43210, USA)

  • Yakang Lin

    (Biochemistry, and Center for Molecular Neurobiology, The Ohio State University, 1060 Carmack Road, Columbus, Ohio 43210, USA)

  • Christopher N. Wyatt

    (Centre for Integrative Physiology, College of Medicine and Veterinary Medicine, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9XD, Scotland, UK)

  • John Parrington

    (University of Oxford, Mansfield Road, Oxford OX1 3QT, UK)

  • Jianjie Ma

    (UMDNJ-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, USA)

  • A. Mark Evans

    (Centre for Integrative Physiology, College of Medicine and Veterinary Medicine, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9XD, Scotland, UK)

  • Antony Galione

    (University of Oxford, Mansfield Road, Oxford OX1 3QT, UK)

  • Michael X. Zhu

    (Biochemistry, and Center for Molecular Neurobiology, The Ohio State University, 1060 Carmack Road, Columbus, Ohio 43210, USA)

Abstract

NAADP calcium mobilization Three signalling molecules cause increases in intracellular Ca2+ levels by triggering release of Ca2+ from intracellular stores due to their action on specific Ca2+-permeable receptors: inositol-1,4,5-trisphosphate binds to and opens the sarcoplasmic reticulum InsP3 receptor; cyclic ADP ribose activates the endoplasmic reticulum ryanodine receptor; but the molecular identity and location of the nicotinic acid adenine dinucleotide phosphate (NAADP) receptor is unknown. Here Calcraft et al. show that the lysosomal two-pore channel, TPC2, is the molecular target of NAADP.

Suggested Citation

  • Peter J. Calcraft & Margarida Ruas & Zui Pan & Xiaotong Cheng & Abdelilah Arredouani & Xuemei Hao & Jisen Tang & Katja Rietdorf & Lydia Teboul & Kai-Ting Chuang & Peihui Lin & Rui Xiao & Chunbo Wang &, 2009. "NAADP mobilizes calcium from acidic organelles through two-pore channels," Nature, Nature, vol. 459(7246), pages 596-600, May.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7246:d:10.1038_nature08030
    DOI: 10.1038/nature08030
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    Cited by:

    1. Qiaochu Wang & Zengge Wang & Yizhen Wang & Zhan Qi & Dayong Bai & Chentong Wang & Yuanying Chen & Wenjian Xu & Xili Zhu & Jaepyo Jeon & Jian Xiong & Chanjuan Hao & Michael Xi Zhu & Aihua Wei & Wei Li, 2023. "A gain-of-function TPC2 variant R210C increases affinity to PI(3,5)P2 and causes lysosome acidification and hypopigmentation," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Palmiro Poltronieri & Nataša Čerekovic, 2018. "Roles of Nicotinamide Adenine Dinucleotide (NAD + ) in Biological Systems," Challenges, MDPI, vol. 9(1), pages 1-14, January.
    3. Yu Yuan & Dawid Jaślan & Taufiq Rahman & Stephen R. Bolsover & Vikas Arige & Larry E. Wagner & Carla Abrahamian & Rachel Tang & Marco Keller & Jonas Hartmann & Anna S. Rosato & Eva-Maria Weiden & Fran, 2022. "Segregated cation flux by TPC2 biases Ca2+ signaling through lysosomes," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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