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Genetic analysis of radiation-induced changes in human gene expression

Author

Listed:
  • Denis A. Smirnov

    (Howard Hughes Medical Institute,)

  • Michael Morley

    (The Children’s Hospital of Philadelphia,)

  • Eunice Shin

    (The Children’s Hospital of Philadelphia,)

  • Richard S. Spielman

    (Department of Genetics and,)

  • Vivian G. Cheung

    (Howard Hughes Medical Institute,
    The Children’s Hospital of Philadelphia,
    Department of Genetics and,
    University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA)

Abstract

Radiation-induced changes in gene expression We are regularly are exposed to radiation from environmental sources, and in medical procedures. To deal with radiation-induced damage, cells mount complex responses that rely on changes in gene expression. It has long been known that individuals vary in their sensitivity to radiation, and this variability is also seen at the gene expression level. Using radiation-induced changes in gene expression as quantitative traits, Smirnov et al. performed genetic linkage and association studies to map their regulators. The results provide new insights into the architecture of gene expression regulation in response to stress and have implications for basic and clinical understanding of how human cells respond to radiation.

Suggested Citation

  • Denis A. Smirnov & Michael Morley & Eunice Shin & Richard S. Spielman & Vivian G. Cheung, 2009. "Genetic analysis of radiation-induced changes in human gene expression," Nature, Nature, vol. 459(7246), pages 587-591, May.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7246:d:10.1038_nature07940
    DOI: 10.1038/nature07940
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    Cited by:

    1. Elin Grundberg & Veronique Adoue & Tony Kwan & Bing Ge & Qing Ling Duan & Kevin C L Lam & Vonda Koka & Andreas Kindmark & Scott T Weiss & Kelan Tantisira & Hans Mallmin & Benjamin A Raby & Olle Nilsso, 2011. "Global Analysis of the Impact of Environmental Perturbation on cis-Regulation of Gene Expression," PLOS Genetics, Public Library of Science, vol. 7(1), pages 1-17, January.
    2. Avital Brodt & Maya Botzman & Eyal David & Irit Gat-Viks, 2014. "Dissecting Dynamic Genetic Variation That Controls Temporal Gene Response in Yeast," PLOS Computational Biology, Public Library of Science, vol. 10(12), pages 1-16, December.

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