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Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

Author

Listed:
  • Olaf Gross

    (III. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675 Munich, Germany
    University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland)

  • Hendrik Poeck

    (III. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675 Munich, Germany)

  • Michael Bscheider

    (Ludwig-Maximilian Universität München)

  • Catherine Dostert

    (University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland)

  • Nicole Hannesschläger

    (III. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675 Munich, Germany)

  • Stefan Endres

    (Ludwig-Maximilian Universität München)

  • Gunther Hartmann

    (Institute of Clinical Chemistry and Pharmacology, Universitätsklinikum Bonn)

  • Aubry Tardivel

    (University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland)

  • Edina Schweighoffer

    (National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • Victor Tybulewicz

    (National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • Attila Mocsai

    (Semmelweis University School of Medicine)

  • Jürg Tschopp

    (University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland)

  • Jürgen Ruland

    (III. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675 Munich, Germany)

Abstract

Beating anti-fungal defences Immunocompromised individuals are at high risk from fungal infection, yet the molecular mechanisms that govern host defence against fungi are not well understood. Gross et al. now show that Candida albicans infection in mice activates the NALP3 inflammasome via a mechanism involving Sky-induced production of reactive oxygen induced by the tyrosine kinase Syk.

Suggested Citation

  • Olaf Gross & Hendrik Poeck & Michael Bscheider & Catherine Dostert & Nicole Hannesschläger & Stefan Endres & Gunther Hartmann & Aubry Tardivel & Edina Schweighoffer & Victor Tybulewicz & Attila Mocsai, 2009. "Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence," Nature, Nature, vol. 459(7245), pages 433-436, May.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7245:d:10.1038_nature07965
    DOI: 10.1038/nature07965
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    Cited by:

    1. Tingting Zhou & Norma V. Solis & Michaela Marshall & Qing Yao & Rachel Garleb & Mengli Yang & Eric Pearlman & Scott G. Filler & Haoping Liu, 2024. "Hyphal Als proteins act as CR3 ligands to promote immune responses against Candida albicans," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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