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qiRNA is a new type of small interfering RNA induced by DNA damage

Author

Listed:
  • Heng-Chi Lee

    (University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA)

  • Shwu-Shin Chang

    (University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA)

  • Swati Choudhary

    (University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA)

  • Antti P. Aalto

    (Biocenter 2, PO Box 56, FIN-00014 University of Helsinki)

  • Mekhala Maiti

    (University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Present address: Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.)

  • Dennis H. Bamford

    (Biocenter 2, PO Box 56, FIN-00014 University of Helsinki)

  • Yi Liu

    (University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA)

Abstract

Damage control: small RNAs involved in DNA repair in Neurospora RNA interference (RNAi) is a gene silencing mechanism conserved from fungi to humans. High-throughput sequencing has highlighted a vast reservoir of small non-coding RNAs in animals and plants, many of whose function remains to be determined. Despite the conservation of the RNAi pathways, whether similar types of small RNAs exist in the lower eukaryotes has been largely unexplored. Now a novel class of small RNAs has been identified in the filamentous fungus Neurospora. Named qiRNAs, for their association with the Argonaute protein QDE-2, like QDE-2 they appear in response to DNA damage. At about 20 nucleotides long they are slightly shorter than Neurospora siRNAs. Neurospora RNAi mutants exhibit increased sensitivity to DNA damage, suggesting a role for qiRNAs in DNA repair as inhibitors of protein translation.

Suggested Citation

  • Heng-Chi Lee & Shwu-Shin Chang & Swati Choudhary & Antti P. Aalto & Mekhala Maiti & Dennis H. Bamford & Yi Liu, 2009. "qiRNA is a new type of small interfering RNA induced by DNA damage," Nature, Nature, vol. 459(7244), pages 274-277, May.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7244:d:10.1038_nature08041
    DOI: 10.1038/nature08041
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    Cited by:

    1. M. J. Gutbrod & B. Roche & J. I. Steinberg & A. A. Lakhani & K. Chang & A. J. Schorn & R. A. Martienssen, 2022. "Dicer promotes genome stability via the bromodomain transcriptional co-activator BRD4," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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