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CBP/p300-mediated acetylation of histone H3 on lysine 56

Author

Listed:
  • Chandrima Das

    (Department of Biochemistry and Molecular Genetics,)

  • M. Scott Lucia

    (and)

  • Kirk C. Hansen

    (Cancer Center Proteomics Core, University of Colorado School of Medicine, PO Box 6511, Aurora Colorado 80045, USA)

  • Jessica K. Tyler

    (Department of Biochemistry and Molecular Genetics,)

Abstract

Chromatin packaging: H3K56ac makes its mark An acetylation mark within the core domain of histone H3, on lysine 56 (H3K56ac), has an important role in chromatin assembly during DNA replication and repair in budding yeast, but it has not been studied in multicellular eukaryotes. Here, two histone acetyl transferase enzymes are shown to acetylate H3K56 in Drosophila and human cells. Histones carrying K56ac are enriched at sites of DNA repair and elevated in several types of cancer.

Suggested Citation

  • Chandrima Das & M. Scott Lucia & Kirk C. Hansen & Jessica K. Tyler, 2009. "CBP/p300-mediated acetylation of histone H3 on lysine 56," Nature, Nature, vol. 459(7243), pages 113-117, May.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7243:d:10.1038_nature07861
    DOI: 10.1038/nature07861
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    Cited by:

    1. Xiao-Ru Ma & Xudong Zhu & Yujie Xiao & Hui-Min Gu & Shuang-Shuang Zheng & Liang Li & Fan Wang & Zhao-Jun Dong & Di-Xian Wang & Yang Wu & Chenyu Yang & Wenhong Jiang & Ke Yao & Yue Yin & Yang Zhang & C, 2022. "Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    2. Masaki Kikuchi & Satoshi Morita & Masatoshi Wakamori & Shin Sato & Tomomi Uchikubo-Kamo & Takehiro Suzuki & Naoshi Dohmae & Mikako Shirouzu & Takashi Umehara, 2023. "Epigenetic mechanisms to propagate histone acetylation by p300/CBP," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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