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Compound vesicle fusion increases quantal size and potentiates synaptic transmission

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  • Liming He

    (National Institute of Neurological Disorders and Stroke, 35 Convent Drive, Building 35, Room 2B-1012, Bethesda, Maryland 20892, USA)

  • Lei Xue

    (National Institute of Neurological Disorders and Stroke, 35 Convent Drive, Building 35, Room 2B-1012, Bethesda, Maryland 20892, USA)

  • Jianhua Xu

    (National Institute of Neurological Disorders and Stroke, 35 Convent Drive, Building 35, Room 2B-1012, Bethesda, Maryland 20892, USA)

  • Benjamin D. McNeil

    (National Institute of Neurological Disorders and Stroke, 35 Convent Drive, Building 35, Room 2B-1012, Bethesda, Maryland 20892, USA)

  • Li Bai

    (National Institute of Neurological Disorders and Stroke, 35 Convent Drive, Building 35, Room 2B-1012, Bethesda, Maryland 20892, USA)

  • Ernestina Melicoff

    (The University of Texas M. D. Anderson Cancer Center, 2121 West Holcombe Boulevard, Box 1100, Houston, Texas 77030, USA)

  • Roberto Adachi

    (The University of Texas M. D. Anderson Cancer Center, 2121 West Holcombe Boulevard, Box 1100, Houston, Texas 77030, USA)

  • Ling-Gang Wu

    (National Institute of Neurological Disorders and Stroke, 35 Convent Drive, Building 35, Room 2B-1012, Bethesda, Maryland 20892, USA)

Abstract

Vesicle fusion in synaptic potentiation Synaptic transmission is believed to function on a quantal mode, that is: through the fusion of one synaptic vesicle with the plasma membrane at a time. New work from Ling-Gang Wu's group at the National Institute of Neurological Disorders and Stroke now describes the fusion of synaptic vesicles with themselves, prior to the release of giant vesicles at a central synapse. The work implicates calcium-dependent synaptotagmin-2 in a mechanism that may apply to previously described compound vesicle fusion in non-neuronal, endocrine cells and at some more peripheral synapses. The study indicates that compound fusion is a significant contributor to synaptic potentiation, with implications for neuronal plasticity and disorders such as epilepsy.

Suggested Citation

  • Liming He & Lei Xue & Jianhua Xu & Benjamin D. McNeil & Li Bai & Ernestina Melicoff & Roberto Adachi & Ling-Gang Wu, 2009. "Compound vesicle fusion increases quantal size and potentiates synaptic transmission," Nature, Nature, vol. 459(7243), pages 93-97, May.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7243:d:10.1038_nature07860
    DOI: 10.1038/nature07860
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    Cited by:

    1. Ling-Gang Wu & Chung Yu Chan, 2024. "Membrane transformations of fusion and budding," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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