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Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay

Author

Listed:
  • Kazufumi Matsushita

    (Laboratory of Host Defense,
    Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan)

  • Osamu Takeuchi

    (Laboratory of Host Defense,
    Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan)

  • Daron M. Standley

    (Laboratory of Systems Immunology, WPI Immunology Frontier Research Center,)

  • Yutaro Kumagai

    (Laboratory of Host Defense,
    Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan)

  • Tatsukata Kawagoe

    (Laboratory of Host Defense,
    Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan)

  • Tohru Miyake

    (Laboratory of Host Defense,
    Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan)

  • Takashi Satoh

    (Laboratory of Host Defense,
    Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan)

  • Hiroki Kato

    (Laboratory of Host Defense,
    Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan)

  • Tohru Tsujimura

    (Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan)

  • Haruki Nakamura

    (Research Center for Structural and Functional Proteomics, Institute for Protein Research, Osaka University, 3-2 Yamada-oka, Suita, Osaka 565-0871, Japan)

  • Shizuo Akira

    (Laboratory of Host Defense,
    Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan)

Abstract

The Zc3h12a gene in innate immunity Here the zinc finger protein encoded by the Zc3h12a gene is shown to be a ribonuclease with an essential role in modulating innate immune responses. Zc3h12a is inducible by Toll-like receptors, and this new work suggests that it inhibits autoimmune disease by controlling the degradation of mRNAs encoding proinflammatory cytokines.

Suggested Citation

  • Kazufumi Matsushita & Osamu Takeuchi & Daron M. Standley & Yutaro Kumagai & Tatsukata Kawagoe & Tohru Miyake & Takashi Satoh & Hiroki Kato & Tohru Tsujimura & Haruki Nakamura & Shizuo Akira, 2009. "Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay," Nature, Nature, vol. 458(7242), pages 1185-1190, April.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7242:d:10.1038_nature07924
    DOI: 10.1038/nature07924
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    Cited by:

    1. Meng Xu & Taku Ito-Kureha & Hyun-Seo Kang & Aleksandar Chernev & Timsse Raj & Kai P. Hoefig & Christine Hohn & Florian Giesert & Yinhu Wang & Wenliang Pan & Natalia Ziętara & Tobias Straub & Regina Fe, 2024. "The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3’-UTR and promoting Rag1 mRNA expression," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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