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Temporally precise in vivo control of intracellular signalling

Author

Listed:
  • Raag D. Airan

    (Department of Bioengineering,)

  • Kimberly R. Thompson

    (Department of Bioengineering,)

  • Lief E. Fenno

    (Department of Bioengineering,)

  • Hannah Bernstein

    (Department of Bioengineering,)

  • Karl Deisseroth

    (Department of Bioengineering,
    Stanford University, Stanford, California 94305, USA)

Abstract

Intracellular signalling: all in good time Ion channels driven by light have provided electrophysiologists with unprecedented control over the activity state of neurons. Here, Deisseroth and colleagues introduce new molecules that offer a similar level of control over signalling pathways to biochemists. Opsin/GPCR chimaeras were engineered, enabling the authors to modulate G-protein activity via light, which in turn could influence neuronal firing. Expressed in vivo, activating these molecules could drive conditioned place preference in behaving mice.

Suggested Citation

  • Raag D. Airan & Kimberly R. Thompson & Lief E. Fenno & Hannah Bernstein & Karl Deisseroth, 2009. "Temporally precise in vivo control of intracellular signalling," Nature, Nature, vol. 458(7241), pages 1025-1029, April.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7241:d:10.1038_nature07926
    DOI: 10.1038/nature07926
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    Cited by:

    1. Fangmin Zhou & Alexandra-Madelaine Tichy & Bibi Nusreen Imambocus & Shreyas Sakharwade & Francisco J. Rodriguez Jimenez & Marco González Martínez & Ishrat Jahan & Margarita Habib & Nina Wilhelmy & Van, 2023. "Optimized design and in vivo application of optogenetically functionalized Drosophila dopamine receptors," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Rouven Schulz & Medina Korkut-Demirbaş & Alessandro Venturino & Gloria Colombo & Sandra Siegert, 2022. "Chimeric GPCRs mimic distinct signaling pathways and modulate microglia responses," Nature Communications, Nature, vol. 13(1), pages 1-26, December.
    3. Tomohiro Sugihara & Takashi Nagata & Benjamin Mason & Mitsumasa Koyanagi & Akihisa Terakita, 2016. "Absorption Characteristics of Vertebrate Non-Visual Opsin, Opn3," PLOS ONE, Public Library of Science, vol. 11(8), pages 1-15, August.
    4. Ahmed Wagdi & Daniela Malan & Udhayabhaskar Sathyanarayanan & Janosch S. Beauchamp & Markus Vogt & David Zipf & Thomas Beiert & Berivan Mansuroglu & Vanessa Dusend & Mark Meininghaus & Linn Schneider , 2022. "Selective optogenetic control of Gq signaling using human Neuropsin," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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