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Glycerol monolaurate prevents mucosal SIV transmission

Author

Listed:
  • Qingsheng Li

    (Medical School, University of Minnesota, MMC 196, 420 Delaware Street S.E., Minneapolis, Minnesota 55455, USA)

  • Jacob D. Estes

    (AIDS and Cancer Virus Program, Science Applications International Corporation–Frederick, Inc., National Cancer Institute, Frederick, Maryland 21702, USA)

  • Patrick M. Schlievert

    (Medical School, University of Minnesota, MMC 196, 420 Delaware Street S.E., Minneapolis, Minnesota 55455, USA)

  • Lijie Duan

    (Medical School, University of Minnesota, MMC 196, 420 Delaware Street S.E., Minneapolis, Minnesota 55455, USA)

  • Amanda J. Brosnahan

    (Medical School, University of Minnesota, MMC 196, 420 Delaware Street S.E., Minneapolis, Minnesota 55455, USA)

  • Peter J. Southern

    (Medical School, University of Minnesota, MMC 196, 420 Delaware Street S.E., Minneapolis, Minnesota 55455, USA)

  • Cavan S. Reilly

    (School of Public Health, University of Minnesota, MMC 303, 420 Delaware Street S.E., Minneapolis, Minnesota 55455, USA)

  • Marnie L. Peterson

    (College of Pharmacy, University of Minnesota, 2001 Sixth Street S.E., Minneapolis, Minnesota 55455, USA)

  • Nancy Schultz-Darken

    (Wisconsin National Primate Research Center, University of Wisconsin, 1220 Capitol Court, Madison, Wisconsin 53715, USA)

  • Kevin G. Brunner

    (Wisconsin National Primate Research Center, University of Wisconsin, 1220 Capitol Court, Madison, Wisconsin 53715, USA)

  • Karla R. Nephew

    (Wisconsin National Primate Research Center, University of Wisconsin, 1220 Capitol Court, Madison, Wisconsin 53715, USA)

  • Stefan Pambuccian

    (Medical School, University of Minnesota, MMC 76, 420 Delaware Street S.E., Minneapolis, Minnesota 55455, USA)

  • Jeffrey D. Lifson

    (AIDS and Cancer Virus Program, Science Applications International Corporation–Frederick, Inc., National Cancer Institute, Frederick, Maryland 21702, USA)

  • John V. Carlis

    (Institute of Technology, University of Minnesota, 200 Union Street S.E., Minneapolis, Minnesota 55455, USA)

  • Ashley T. Haase

    (Medical School, University of Minnesota, MMC 196, 420 Delaware Street S.E., Minneapolis, Minnesota 55455, USA)

Abstract

HIV/AIDS prevention Clinical trials of microbicides as a means of preventing the transmission of HIV-1 to women have proved disappointing. Now a study in the simian immunodeficiency virus (SIV)–rhesus macaque vaginal transmission model for HIV infection suggests that a prophylactic approach might yet be worth pursuing. The commonly used antimicrobial compound glycerol monolaurate (GML) was found to suppress SIV infection even after repeated virus exposure. But its mechanism of action was surprising. The host's inflammatory response to the virus, rather than helping, was shown to fuel the infection by recruiting the very CD4+ T cells that the virus targets. GML's prophylactic action appeared to result from its ability to block this host response, rather than from a direct effect on the virus. This points to cell signalling and innate host responses in the mucosal cells as potential targets for drugs and vaccines aimed at preventing infection by HIV — and by other pathogens too if they use similar infection strategies.

Suggested Citation

  • Qingsheng Li & Jacob D. Estes & Patrick M. Schlievert & Lijie Duan & Amanda J. Brosnahan & Peter J. Southern & Cavan S. Reilly & Marnie L. Peterson & Nancy Schultz-Darken & Kevin G. Brunner & Karla R., 2009. "Glycerol monolaurate prevents mucosal SIV transmission," Nature, Nature, vol. 458(7241), pages 1034-1038, April.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7241:d:10.1038_nature07831
    DOI: 10.1038/nature07831
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    Cited by:

    1. Junjun Jiang & Xiaoyi Yang & Li Ye & Bo Zhou & Chuanyi Ning & Jiegang Huang & Bingyu Liang & Xiaoni Zhong & Ailong Huang & Renchuan Tao & Cunwei Cao & Hui Chen & Hao Liang, 2014. "Pre-Exposure Prophylaxis for the Prevention of HIV Infection in High Risk Populations: A Meta-Analysis of Randomized Controlled Trials," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-8, February.

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