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Gene regulatory logic of dopamine neuron differentiation

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  • Nuria Flames

    (Howard Hughes Medical Institute, Columbia University Medical Center, New York, New York 10032, USA)

  • Oliver Hobert

    (Howard Hughes Medical Institute, Columbia University Medical Center, New York, New York 10032, USA)

Abstract

Directing dopaminergic differentiation Neurons that produce dopamine as a neurotransmitter control a broad variety of brain functions, including motor control, cognition, motivation and pleasure. How precursor cells converge onto the dopaminergic fate across the vast diversity of developmental lineages involved in those functions has been unclear. Nuria Flames and Oliver Hobert now report that the regulatory protein AST-1 is necessary and sufficient to drive and maintain the terminal differentiation of dopaminergic neurons in the nematode C. elegans. As the protein and its terminal differentiation function are strikingly conserved in mice, the results have direct implications for stem-cell replacement strategies in dopamine-related disorders such as Parkinson's disease.

Suggested Citation

  • Nuria Flames & Oliver Hobert, 2009. "Gene regulatory logic of dopamine neuron differentiation," Nature, Nature, vol. 458(7240), pages 885-889, April.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7240:d:10.1038_nature07929
    DOI: 10.1038/nature07929
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    Cited by:

    1. Zihao Wang & Qian Zhang & Yayun Jiang & Jun Zhou & Ye Tian, 2024. "ASI-RIM neuronal axis regulates systemic mitochondrial stress response via TGF-β signaling cascade," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Ian G. Char & Manuel E. Lladser, 2020. "Stochastic Analysis of Minimal Automata Growth for Generalized Strings," Methodology and Computing in Applied Probability, Springer, vol. 22(1), pages 329-347, March.

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