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IFNα activates dormant haematopoietic stem cells in vivo

Author

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  • Marieke A. G. Essers

    (Deutsches Krebsforschungszentrum (DKFZ), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany
    Heidelberg Institute for Stem Cell Technologies and Experimental Medicine (HI-STEM), Im Neuenheimer Feld 280. D-69120 Heidelberg, Germany)

  • Sandra Offner

    (Ecole Polytechnique Fédérale de Lausanne (EPFL), ISREC—Swiss Institute for Experimental Cancer Research, School of Life Science)

  • William E. Blanco-Bose

    (Ecole Polytechnique Fédérale de Lausanne (EPFL), ISREC—Swiss Institute for Experimental Cancer Research, School of Life Science)

  • Zoe Waibler

    (Paul Ehrlich Institute)

  • Ulrich Kalinke

    (Paul Ehrlich Institute
    TWINCORE—Centre for Experimental and Clinical Infection Research Feodor-Lynen-Str. 7)

  • Michel A. Duchosal

    (Service and Central Laboratory of Hematology, CHUV, University Hospitals of Lausanne)

  • Andreas Trumpp

    (Deutsches Krebsforschungszentrum (DKFZ), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany
    Heidelberg Institute for Stem Cell Technologies and Experimental Medicine (HI-STEM), Im Neuenheimer Feld 280. D-69120 Heidelberg, Germany
    Ecole Polytechnique Fédérale de Lausanne (EPFL), ISREC—Swiss Institute for Experimental Cancer Research, School of Life Science)

Abstract

Stem cell activation by IFNα Haematopoietic stem cells (HSCs) exist in a dormant state until called upon, in the event of injury, to proliferate in order to quickly repair damaged tissue. This paper shows that in response to treatment of mice with interferon-α (IFNα), HSCs enter an active cell cycle, increase phosphorylation of STAT1 and PKB/Akt, express IFNα target genes and up-regulate stem cell antigen-1 (Sca-1). While chronic activation of the IFNα pathway in HSCs impairs their function, acute IFNa treatment promotes the proliferation of dormant HSCs in vivo. These data may help to clarify the so far unexplained clinical effects of IFNα on leukaemic cells and raise the possibility for novel applications of type I interferons to target cancer stem cells.

Suggested Citation

  • Marieke A. G. Essers & Sandra Offner & William E. Blanco-Bose & Zoe Waibler & Ulrich Kalinke & Michel A. Duchosal & Andreas Trumpp, 2009. "IFNα activates dormant haematopoietic stem cells in vivo," Nature, Nature, vol. 458(7240), pages 904-908, April.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7240:d:10.1038_nature07815
    DOI: 10.1038/nature07815
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    Cited by:

    1. Pan, Sonjoy & Raha, Soumyendu & Chakrabarty, Siddhartha P., 2020. "A quantitative study on the role of TKI combined with Wnt/β-catenin signaling and IFN-α in the treatment of CML through deterministic and stochastic approaches," Chaos, Solitons & Fractals, Elsevier, vol. 133(C).

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