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Identification of a dendritic cell receptor that couples sensing of necrosis to immunity

Author

Listed:
  • David Sancho

    (Immunobiology Laboratory,)

  • Olivier P. Joffre

    (Immunobiology Laboratory,)

  • Anna M. Keller

    (Immunobiology Laboratory,)

  • Neil C. Rogers

    (Immunobiology Laboratory,)

  • Dolores Martínez

    (FACS Laboratory, Cancer Research UK, London Research Institute, Lincoln’s Inn Fields Laboratories, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK)

  • Patricia Hernanz-Falcón

    (Immunobiology Laboratory,)

  • Ian Rosewell

    (Trangenic Services, Cancer Research UK, Clare Hall Laboratories, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3LD, UK)

  • Caetano Reis e Sousa

    (Immunobiology Laboratory,)

Abstract

Necrosis recognition linked to immunity Necrotic cell corpses accumulate in tissues as a result of injury or impaired clearance of apoptotic cells, and can induce an inflammatory response that initiates tissue repair. The recently described dendritic C-type lectin receptor CLEC9A, also called DNGR-1, is shown to sense necrotic debris by recognizing a preformed signal that is exposed on necrotic cells, and to mediate cross presentation of dead cell-associated antigens.

Suggested Citation

  • David Sancho & Olivier P. Joffre & Anna M. Keller & Neil C. Rogers & Dolores Martínez & Patricia Hernanz-Falcón & Ian Rosewell & Caetano Reis e Sousa, 2009. "Identification of a dendritic cell receptor that couples sensing of necrosis to immunity," Nature, Nature, vol. 458(7240), pages 899-903, April.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7240:d:10.1038_nature07750
    DOI: 10.1038/nature07750
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    Cited by:

    1. Hongkui Xiao & Isabel Ulmert & Luisa Bach & Johanna Huber & Hamsa Narasimhan & Ilia Kurochkin & Yinshui Chang & Signe Holst & Urs Mörbe & Lili Zhang & Andreas Schlitzer & Carlos-Filipe Pereira & Barba, 2024. "Genomic deletion of Bcl6 differentially affects conventional dendritic cell subsets and compromises Tfh/Tfr/Th17 cell responses," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Bartosz Wiernicki & Sophia Maschalidi & Jonathan Pinney & Sandy Adjemian & Tom Vanden Berghe & Kodi S. Ravichandran & Peter Vandenabeele, 2022. "Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Barbara M Schulte & Paul R Gielen & Esther D Kers-Rebel & Gerty Schreibelt & Frank J M van Kuppeveld & Gosse J Adema, 2015. "Enterovirus-Infected β-Cells Induce Distinct Response Patterns in BDCA1+ and BDCA3+ Human Dendritic Cells," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-17, March.

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