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Clustering of InsP3 receptors by InsP3 retunes their regulation by InsP3 and Ca2+

Author

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  • Taufiq-Ur-Rahman

    (Tennis Court Road, Cambridge CB2 1PD, UK)

  • Alexander Skupin

    (Mathematical Cell Physiology, Max Delbrück Centre for Molecular Medicine, Robert Rössle Str. 10, 13092 Berlin, Germany)

  • Martin Falcke

    (Mathematical Cell Physiology, Max Delbrück Centre for Molecular Medicine, Robert Rössle Str. 10, 13092 Berlin, Germany
    Helmholtz Centre Berlin for Materials and Energy, Glienicker Str. 100, 14109 Berlin, Germany)

  • Colin W. Taylor

    (Tennis Court Road, Cambridge CB2 1PD, UK)

Abstract

InsP3 receptors and channel opening Inositol trisphosphate (InsP3) is a second messenger that triggers release of Ca2+ from intracellular stores through its cognate receptor — a ligand-gated ion channel. This paper shows that InsP3 receptors aggregate in response to InsP3, resulting in a lower probability of channel opening, and that increases in intracellular Ca2+ can effectively relieve this inhibition and enhance the coupling between receptors in a cluster. This mechanism may serve to enhance the sensitivity to changes in intracellular Ca2+.

Suggested Citation

  • Taufiq-Ur-Rahman & Alexander Skupin & Martin Falcke & Colin W. Taylor, 2009. "Clustering of InsP3 receptors by InsP3 retunes their regulation by InsP3 and Ca2+," Nature, Nature, vol. 458(7238), pages 655-659, April.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7238:d:10.1038_nature07763
    DOI: 10.1038/nature07763
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    Cited by:

    1. Eunbyul Cho & Youngsik Woo & Yeongjun Suh & Bo Kyoung Suh & Soo Jeong Kim & Truong Thi My Nhung & Jin Yeong Yoo & Tran Diem Nghi & Su Been Lee & Dong Jin Mun & Sang Ki Park, 2023. "Ratiometric measurement of MAM Ca2+ dynamics using a modified CalfluxVTN," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Duan, Wei-Long & Zeng, Chunhua, 2017. "Statistics for anti-synchronization of intracellular calcium dynamics," Applied Mathematics and Computation, Elsevier, vol. 293(C), pages 611-616.

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