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FGF signalling during embryo development regulates cilia length in diverse epithelia

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  • Judith M. Neugebauer

    (University of Utah School of Medicine, Eccles Institute of Human Genetics, Building 533, Room 3160, 15 North 2030 East, Salt Lake City, Utah 84112-5330, USA)

  • Jeffrey D. Amack

    (University of Utah School of Medicine, Eccles Institute of Human Genetics, Building 533, Room 3160, 15 North 2030 East, Salt Lake City, Utah 84112-5330, USA
    Present address: Department of Cell and Developmental Biology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, New York 13210, USA.)

  • Annita G. Peterson

    (University of Utah School of Medicine, Eccles Institute of Human Genetics, Building 533, Room 3160, 15 North 2030 East, Salt Lake City, Utah 84112-5330, USA)

  • Brent W. Bisgrove

    (University of Utah School of Medicine, Eccles Institute of Human Genetics, Building 533, Room 3160, 15 North 2030 East, Salt Lake City, Utah 84112-5330, USA)

  • H. Joseph Yost

    (University of Utah School of Medicine, Eccles Institute of Human Genetics, Building 533, Room 3160, 15 North 2030 East, Salt Lake City, Utah 84112-5330, USA)

Abstract

FGF signalling and cilia function Neugebauer et al. show that fibroblast growth factor (FGF) signalling regulates cilia length and function in diverse epithelia during zebrafish and Xenopus development. Reducing FGF signalling reduces cilia length and perturbs directional fluid flow required for left–right patterning of the embryo, as well as shorter tethering cilia in organs of the inner ear and kidneys. They propose that some developmental defects and diseases ascribed to FGF signalling are due in part to loss of cilia function.

Suggested Citation

  • Judith M. Neugebauer & Jeffrey D. Amack & Annita G. Peterson & Brent W. Bisgrove & H. Joseph Yost, 2009. "FGF signalling during embryo development regulates cilia length in diverse epithelia," Nature, Nature, vol. 458(7238), pages 651-654, April.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7238:d:10.1038_nature07753
    DOI: 10.1038/nature07753
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    Cited by:

    1. Hyeyoon Lee & Celine Marie Camuto & Christof Niehrs, 2024. "R-Spondin 2 governs Xenopus left-right body axis formation by establishing an FGF signaling gradient," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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